Phosphonic acid, [[(2S,3R,4R,5R)-1-(1-oxo-2-propenyl)-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-2-pyrrolidinyl](phenylseleno)methyl]-, dimethyl ester

Base Information

Chemical Name:Phosphonic acid, [[(2S,3R,4R,5R)-1-(1-oxo-2-propenyl)-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-2-pyrrolidinyl](phenylseleno)methyl]-, dimethyl ester
CAS No.:397242-88-5
Molecular Formula:C38H42NO7PSe
Molecular Weight:734.688
Hs Code.:

Phosphonic acid,
[[(2S,3R,4R,5R)-1-(1-oxo-2-propenyl)-3,4-bis(phenylmethoxy)-5-[(phen
ylmethoxy)methyl]-2-pyrrolidinyl](phenylseleno)methyl]-, dimethyl ester

Synonyms:

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Chemical Property of Phosphonic acid, [[(2S,3R,4R,5R)-1-(1-oxo-2-propenyl)-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-2-pyrrolidinyl](phenylseleno)methyl]-, dimethyl ester

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Technology Process of Phosphonic acid, [[(2S,3R,4R,5R)-1-(1-oxo-2-propenyl)-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-2-pyrrolidinyl](phenylseleno)methyl]-, dimethyl ester

There total 9 articles about Phosphonic acid, [[(2S,3R,4R,5R)-1-(1-oxo-2-propenyl)-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-2-pyrrolidinyl](phenylseleno)methyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 814-68-6,25189-84-8
acryloyl chloride

: 397242-85-2
[((2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl)-phenylselanyl-methyl]-phosphonic acid dimethyl ester

: 397242-88-5
[((2S,3R,4R,5R)-1-Acryloyl-3,4-bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl)-phenylselanyl-methyl]-phosphonic acid dimethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 397242-88-5
[((2S,3R,4R,5R)-1-Acryloyl-3,4-bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl)-phenylselanyl-methyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / -78 °C

1.2: ZnCl₂ / -78 °C

1.3: 64 percent / -78 °C

2.1: 69 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 64 percent / NEt₃ / CH₂Cl₂ / 2 h / 0 °C

With n-butyllithium; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: lithium dimethyl phenylselenylmethylphosphonate

: 397242-88-5
[((2S,3R,4R,5R)-1-Acryloyl-3,4-bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl)-phenylselanyl-methyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 - 20 °C

2: 64 percent / NEt₃ / CH₂Cl₂ / 2 h / 0 °C

With boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(01)01684-7