1-Pyrrolidinecarboxylic acid, 2-[(dimethoxyphosphinyl)methylene]-3,4-bis(phenylmethoxy)-5-[(phenyl methoxy)methyl]-, phenylmethyl ester, (2E,3R,4R,5R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(dimethoxyphosphinyl)methylene]-3,4-bis(phenylmethoxy)-5-[(phenyl methoxy)methyl]-, phenylmethyl ester, (2E,3R,4R,5R)-
CAS No.:397242-89-6
Molecular Formula:C37H40NO8P
Molecular Weight:657.7
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(dimethoxyphosphinyl)methylene]-3,4-bis(phenylmethoxy)-5-[(phenyl
methoxy)methyl]-, phenylmethyl ester, (2E,3R,4R,5R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(dimethoxyphosphinyl)methylene]-3,4-bis(phenylmethoxy)-5-[(phenyl methoxy)methyl]-, phenylmethyl ester, (2E,3R,4R,5R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(dimethoxyphosphinyl)methylene]-3,4-bis(phenylmethoxy)-5-[(phenyl methoxy)methyl]-, phenylmethyl ester, (2E,3R,4R,5R)-

There total 9 articles about 1-Pyrrolidinecarboxylic acid, 2-[(dimethoxyphosphinyl)methylene]-3,4-bis(phenylmethoxy)-5-[(phenyl methoxy)methyl]-, phenylmethyl ester, (2E,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 397242-86-3
(2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(R)-(dimethoxy-phosphoryl)-phenylselanyl-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

: 397242-92-1
(2R,3R,4R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[1-(dimethoxy-phosphoryl)-meth-(Z)-ylidene]-pyrrolidine-1-carboxylic acid benzyl ester

: 397242-89-6
(2R,3R,4R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[1-(dimethoxy-phosphoryl)-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 4 ℃; for 16h;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 397242-89-6
(2R,3R,4R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[1-(dimethoxy-phosphoryl)-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 1.5 h / 20 °C

2: mCPBA / CH₂Cl₂ / 16 h / 4 °C

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: 397242-80-7
(2R,3R,4R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-3,4-dihydro-2H-pyrrole

: 397242-89-6
(2R,3R,4R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[1-(dimethoxy-phosphoryl)-meth-(E)-ylidene]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 - 20 °C

2: 48 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 1.5 h / 20 °C

3: mCPBA / CH₂Cl₂ / 16 h / 4 °C

With boron trifluoride diethyl etherate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4039(01)01684-7