1-Pyrrolidinecarboxylic acid, 2-[(R)-(dimethoxyphosphinyl)(phenylseleno)methyl]-3,4-bis(phenylmeth oxy)-5-[(phenylmethoxy)methyl]-, phenylmethyl ester, (2S,3R,4R,5R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(R)-(dimethoxyphosphinyl)(phenylseleno)methyl]-3,4-bis(phenylmeth oxy)-5-[(phenylmethoxy)methyl]-, phenylmethyl ester, (2S,3R,4R,5R)-
CAS No.:397242-86-3
Molecular Formula:C43H46NO8PSe
Molecular Weight:814.774
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(R)-(dimethoxyphosphinyl)(phenylseleno)methyl]-3,4-bis(phenylmeth
oxy)-5-[(phenylmethoxy)methyl]-, phenylmethyl ester, (2S,3R,4R,5R)-

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(R)-(dimethoxyphosphinyl)(phenylseleno)methyl]-3,4-bis(phenylmeth oxy)-5-[(phenylmethoxy)methyl]-, phenylmethyl ester, (2S,3R,4R,5R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(R)-(dimethoxyphosphinyl)(phenylseleno)methyl]-3,4-bis(phenylmeth oxy)-5-[(phenylmethoxy)methyl]-, phenylmethyl ester, (2S,3R,4R,5R)-

There total 9 articles about 1-Pyrrolidinecarboxylic acid, 2-[(R)-(dimethoxyphosphinyl)(phenylseleno)methyl]-3,4-bis(phenylmeth oxy)-5-[(phenylmethoxy)methyl]-, phenylmethyl ester, (2S,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 397242-85-2
[((2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-pyrrolidin-2-yl)-phenylselanyl-methyl]-phosphonic acid dimethyl ester

: 397242-91-0
(2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(S)-(dimethoxy-phosphoryl)-phenylselanyl-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

: 397242-86-3
(2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(R)-(dimethoxy-phosphoryl)-phenylselanyl-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With sodium carbonate; In dichloromethane; water; at 20 ℃; for 1.5h;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 397242-86-3
(2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(R)-(dimethoxy-phosphoryl)-phenylselanyl-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / -78 °C

1.2: ZnCl₂ / -78 °C

1.3: 64 percent / -78 °C

2.1: 69 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 48 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 1.5 h / 20 °C

With n-butyllithium; boron trifluoride diethyl etherate; sodium carbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4039(01)01684-7

Reference yield:

: lithium dimethyl phenylselenylmethylphosphonate

: 397242-86-3
(2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-5-[(R)-(dimethoxy-phosphoryl)-phenylselanyl-methyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / BF₃*OEt₂ / tetrahydrofuran / 2 h / -78 - 20 °C

2: 48 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 1.5 h / 20 °C

With boron trifluoride diethyl etherate; sodium carbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4039(01)01684-7