L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-3-(triphenylmethyl)-L-histidyl-L-leuc yl-3-(triphenylmethyl)-L-histidyl-

Base Information

Chemical Name:L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-3-(triphenylmethyl)-L-histidyl-L-leuc yl-3-(triphenylmethyl)-L-histidyl-
CAS No.:397247-63-1
Molecular Formula:C76H84N10O7
Molecular Weight:1249.57
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-3-(triphenylmethyl)-L-histidyl-L-leuc yl-3-(triphenylmethyl)-L-histidyl-

Chemical Property:

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Technology Process of L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-3-(triphenylmethyl)-L-histidyl-L-leuc yl-3-(triphenylmethyl)-L-histidyl-

There total 8 articles about L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-3-(triphenylmethyl)-L-histidyl-L-leuc yl-3-(triphenylmethyl)-L-histidyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 397247-62-0
H-His(Trt)-Leu-His(Trt)-Leu-NH₂

: 2018-66-8
Z-Leu-OH

: 397247-63-1
Z-Leu-His(Trt)-Leu-His(Trt)-Leu-NH₂

Guidance literature:: With TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/ol016914n

Reference yield:

: 397247-57-3
Fmoc-His(Trt)-Leu-NH₂

: 397247-63-1
Z-Leu-His(Trt)-Leu-His(Trt)-Leu-NH₂

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / piperidine / dimethylformamide / 0.08 h / 20 °C

2: 80 percent / EDC*HCl; HOBt; TEA / CH₂Cl₂ / 20 °C

3: 90 percent / H₂ / Pd/C / methanol / 2 h

4: 89 percent / EDC*HCl; HOBt; TEA / CH₂Cl₂ / 20 °C

5: 100 percent / piperidine / dimethylformamide / 20 °C

6: 89 percent / EDC*HCl; HOBt; TEA / CH₂Cl₂ / 20 °C

With piperidine; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol016914n

Reference yield:

: 397247-58-4
H-His(Trt)-Leu-NH₂

: 397247-63-1
Z-Leu-His(Trt)-Leu-His(Trt)-Leu-NH₂

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / EDC*HCl; HOBt; TEA / CH₂Cl₂ / 20 °C

2: 90 percent / H₂ / Pd/C / methanol / 2 h

3: 89 percent / EDC*HCl; HOBt; TEA / CH₂Cl₂ / 20 °C

4: 100 percent / piperidine / dimethylformamide / 20 °C

5: 89 percent / EDC*HCl; HOBt; TEA / CH₂Cl₂ / 20 °C

With piperidine; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol016914n