(9bR)-1aα,3-Dimethyl-1a,2,3,3aα,4,6-hexahydro-1H-cyclopropa[c]indolo[4,3-ef]indole

Base Information

Chemical Name:(9bR)-1aα,3-Dimethyl-1a,2,3,3aα,4,6-hexahydro-1H-cyclopropa[c]indolo[4,3-ef]indole
CAS No.:26057-57-8
Molecular Formula:C₁₆H₁₈N₂
Molecular Weight:238.332
Hs Code.:2933990090

Synonyms:1H-Cycloprop[c]indolo[4,3-ef]indole,1a,2,3,3a,4,6-hexahydro-1a,3-dimethyl-, (1aR,3aR,9bR)- (9CI); Cycloclavin;Cycloclavine

Suppliers and Price of (9bR)-1aα,3-Dimethyl-1a,2,3,3aα,4,6-hexahydro-1H-cyclopropa[c]indolo[4,3-ef]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (9bR)-1aα,3-Dimethyl-1a,2,3,3aα,4,6-hexahydro-1H-cyclopropa[c]indolo[4,3-ef]indole

Chemical Property:

Vapor Pressure:5.94E-07mmHg at 25°C
Boiling Point:410.6°Cat760mmHg
Flash Point:202.1°C
PSA：19.03000
Density:1.28g/cm³
LogP:2.62370

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (9bR)-1aα,3-Dimethyl-1a,2,3,3aα,4,6-hexahydro-1H-cyclopropa[c]indolo[4,3-ef]indole

There total 7 articles about (9bR)-1aα,3-Dimethyl-1a,2,3,3aα,4,6-hexahydro-1H-cyclopropa[c]indolo[4,3-ef]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (1aS,3aR,9bS)-1a,3-dimethyl-3,3a,4,6-tetrahydro-1H-cyclopropa[c]indolo[4,3-ef]indol-2(1aH)-one

: 26057-57-8
(+)-cycloclavine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 16h; Inert atmosphere; Sealed tube; Reflux;
DOI:10.1055/s-0037-1610395

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₁₅H₁₆N₂

: 26057-57-8
Cycloclavine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 2h;
DOI:10.1021/acs.orglett.9b02015

Reference yield:

: C₂₅H₂₈N₂O₄S

: 26057-57-8
(+)-cycloclavine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 1 h

2: naphthalene; sodium / tetrahydrofuran / 0.17 h / -78 °C

3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 16 h / 0 °C / Inert atmosphere; Reflux; Sealed tube

With lithium aluminium tetrahydride; naphthalene; sodium; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/acs.orglett.9b02015