Technology Process of L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,
[3-[4-(1,1-dimethylethoxy)-4-oxobutoxy]-5-methoxyphenyl](2-phenyl-1,3-
dithian-2-yl)methyl ester
There total 8 articles about L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,
[3-[4-(1,1-dimethylethoxy)-4-oxobutoxy]-5-methoxyphenyl](2-phenyl-1,3-
dithian-2-yl)methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; PS-carbodiimide resin;
In
dichloromethane;
at 20 ℃;
for 5h;
DOI:10.1021/jo010703e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C
1.2: tetrahydrofuran / 2.5 h / 20 °C
1.3: 80 percent / pyridine / tetrahydrofuran / 0.5 h
2.1: 81 percent / HF*pyr / tetrahydrofuran / 0 °C
3.1: 75 percent / tetrabutylammonium iodide; K2CO3 / acetonitrile / 20 h / 90 °C
4.1: 95 percent / K2CO3; Et3N / methanol; H2O / 3 h / 70 °C
5.1: 90 percent / PS-carbodiimide resin; DMAP / CH2Cl2 / 5 h / 20 °C
With
dmap; n-butyllithium; PS-carbodiimide resin; tetra-(n-butyl)ammonium iodide; potassium carbonate; pyridine hydrogenfluoride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo010703e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 93 percent / DIPEA / CH2Cl2; diethyl ether / 24 h
2.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C
2.2: tetrahydrofuran / 2.5 h / 20 °C
2.3: 80 percent / pyridine / tetrahydrofuran / 0.5 h
3.1: 81 percent / HF*pyr / tetrahydrofuran / 0 °C
4.1: 75 percent / tetrabutylammonium iodide; K2CO3 / acetonitrile / 20 h / 90 °C
5.1: 95 percent / K2CO3; Et3N / methanol; H2O / 3 h / 70 °C
6.1: 90 percent / PS-carbodiimide resin; DMAP / CH2Cl2 / 5 h / 20 °C
With
dmap; n-butyllithium; PS-carbodiimide resin; tetra-(n-butyl)ammonium iodide; potassium carbonate; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jo010703e
