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57179-35-8 Usage


3-Methoxy-5-hydroxybenzaldehyde, also known as Vanillin, is an organic compound that belongs to the class of aromatic aldehydes. It is characterized by the presence of a methoxy group at the 3rd position and a hydroxy group at the 5th position on a benzene ring, with an aldehyde functional group attached to the 1st position. This versatile compound is known for its distinctive aroma and is widely used in various industries due to its unique properties.


Used in Pharmaceutical Industry:
3-Methoxy-5-hydroxybenzaldehyde is used as an intermediate for the synthesis of various pharmaceutical compounds. Its ability to form a wide range of derivatives makes it a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Flavor and Fragrance Industry:
3-Methoxy-5-hydroxybenzaldehyde is used as a key component in the creation of artificial vanilla flavoring. Its characteristic sweet, creamy, and slightly woody aroma is highly sought after in the food and beverage industry, as well as in the production of perfumes and cosmetics.
Used in Chemical Synthesis:
3-Methoxy-5-hydroxybenzaldehyde is used for the synthesis of Phenathrenes from cyclophanes. These complex organic molecules have potential applications in various fields, including materials science and medicinal chemistry, due to their unique structural and electronic properties.

Check Digit Verification of cas no

The CAS Registry Mumber 57179-35-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,1,7 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 57179-35:
148 % 10 = 8
So 57179-35-8 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 3-Hydroxy-5-methoxybenzaldehyde

1.2 Other means of identification

Product number -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57179-35-8 SDS

57179-35-8Relevant articles and documents

Utilizing a copper-free Sonogashira reaction in the synthesis of the leukotriene a4 hydrolase modulator batatasin IV

Petruncio, Greg,Girgis, Michael,Moummi, Sanae,Jayatilake, Meth,Lee, Kyung Hyeon,Paige, Mikell

supporting information, (2020/10/27)

Batatasin IV is a dihydrostilbenoid isolated from Chinese yams which was shown to have inhibitory activities against plant growth. Later studies showed that this compound may exhibit anti-inflammatory properties by inhibiting the epoxide hydrolase activity of the leukotriene A4 hydrolase enzyme. To access the dihydrostilbenoid skeleton, a copper-free SPhos-mediated Sonogashira reaction was conceived and the substrate scope was explored. Our results indicate that the reaction can tolerate the presence of free alcohols, aldehydes, nitro groups, and anilinyl groups. However, a substituent with an acidic phenol or carboxylic acid group gave significantly lower yields. Next, a total synthesis of batatasin IV was accomplished in 16% overall yield incorporating the reported copper-free Sonogashira reaction. Finally, we show that batatasin IV inhibits the hydrolysis of alanine p-nitroanilide by leukotriene A4 hydrolase with an IC50 of 91.4 μM.

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus

Fetzer, Christian,Korotkov, Vadim S.,Th?nert, Robert,Lee, Kyu Myung,Neuenschwander, Martin,von Kries, Jens Peter,Medina, Eva,Sieber, Stephan A.

supporting information, p. 15746 - 15750 (2017/10/20)

The Staphylococcus aureus ClpXP protease is an important regulator of cell homeostasis and virulence. We utilized a high-throughput screen against the ClpXP complex and identified a specific inhibitor of the ClpX chaperone that disrupts its oligomeric sta

Synthesis and biological evaluation of novel gigantol derivatives as potential agents in prevention of diabetic cataract

Wu, Jie,Lu, Chuanjun,Li, Xue,Fang, Hua,Wan, Wencheng,Yang, Qiaohong,Sun, Xiaosheng,Wang, Meiling,Hu, Xiaohong,Chen, C.-Y. Oliver,Wei, Xiaoyong

, (2015/12/26)

As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts. To improve its bioefficacy and facilitate use as a therapeutic agent, gigantol (compound 14f) and a series of novel analogs were designed and synthesized. Analogs were formulated to have different substituents on the phenyl ring (compounds 4, 5, 8, 14a-e), substitute the phenyl ring with a larger steric hindrance ring (compounds 10, 17c) or modify the carbon chain (compounds 17a, 17b, 21, 23, 25). All of the analogs were tested for their effect on AR and iNOS activities and on D-galactose-induced apoptosis in cultured human lens epithelial cells. Compounds 5, 10, 14a, 14b, 14d, 14e, 14f, 17b, 17c, 23, and 25 inhibited AR activity, with IC50 values ranging from 5.02 to 288.8 μM. Compounds 5, 10, 14b, and 14f inhibited iNOS activity with IC50 ranging from 432.6 to 1188.7 μM. Compounds 5, 8, 10, 14b, 14f, and 17c protected the cells from D-galactose induced apoptosis with viability ranging from 55.2 to 76.26%. Of gigantol and its analogs, compound 10 showed the greatest bioefficacy and is warranted to be developed as a therapeutic agent for diabetic cataracts.

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