Technology Process of 2,2-Difluoro-1,3-benzodioxole-5-acetic acid
There total 1 articles about 2,2-Difluoro-1,3-benzodioxole-5-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C16H12F2O4;
With
methanol; sodium hydroxide; water;
at 20 ℃;
for 18h;
With
hydrogenchloride;
In
water;
pH=3 - 4;
- Guidance literature:
-
With
triethylamine; HATU;
In
dichloromethane;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: HATU; triethylamine / dichloromethane / 18 h / 20 °C
2: Lawessons reagent / tetrahydrofuran / 13 h / 70 °C
3: palladium 10% on activated carbon / N,N-dimethyl-formamide / 11 h / 50 °C / Inert atmosphere
4: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 17 h / 95 °C / Inert atmosphere
5: hydroxylamine hydrochloride / methanol / 3 h / 20 °C
6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C
With
Lawessons reagent; tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; hydroxylamine hydrochloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
