66416-72-6

Basic information

• Product Name: 4-BROMO-2-IODOANILINE
• Synonyms: 4-Bromo-2-iodoaniline 97%;4-bromo-2-iodo-benzenamine;ASISCHEM T54343;4-BROMO-2-IODOANILINE;4-BROMO-2-IODO-PHENYLAMINE;AKOS BB-7878;4-Bromo-2-iodoaniline,97%;BenzenaMine, 4-broMo-2-iodo-
• CAS NO: 66416-72-6
• Molecular Formula: C₆H₅BrIN
• Molecular Weight: 297.92
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Bromine Compounds;Iodine Compounds;Amines;C2 to C6;Nitrogen Compounds
• Mol File: 66416-72-6.mol
• Article Data: 36

Chemical Properties

• Melting Point: 69-72 °C(lit.)
• Boiling Point: 297.9°C at 760 mmHg
• Flash Point: 134°C
• Appearance: Gray to purple/Powder
• Density: 2.292g/cm³
• Vapor Pressure: 0.00131mmHg at 25°C
• Refractive Index: 1.715
• Storage Temp.: Refrigerated.
• Solubility: soluble in Methanol
• PKA: 1.83±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-2-IODOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-IODOANILINE(66416-72-6)
• EPA Substance Registry System: 4-BROMO-2-IODOANILINE(66416-72-6)

Safety Data

• Hazard Codes: T,N,Xi
• Statements: 25-37/38-41-51/53
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 66416-72-6(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-iodoaniline may be used in the following:Preparation of quinolone derivatives.Synthesis of a resin-bound sulfonamide, which was used as a starting material for the preparation of 2,3,5-trisubstituted indoles.

General Description

4-Bromo-2-iodoaniline is a 2-iodoaniline derivative. It can be prepared by reacting 4-bromoaniline with iodine.

InChI:InChI=1/C6H5BrIN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

Upstream product

• 106-40-1 4-bromo-aniline 
• 615-43-0 2-iodophenylamine 
• 62-53-3 aniline 

Downstream Products

• 5304-21-2 6-bromo-2-methylbenzothiazole 
• 71205-21-5 methyl (E)-3-(2-amino-5-bromophenyl)prop-2-enoate 
• 89280-77-3 4-bromo-2,6-diiodoaniline 
• 543740-87-0 2-[(2-amino-5-bromophenyl)ethynyl]-4,6-dibromophenylamine 
• 7254-19-5 5-bromo-2-indolecarboxylic acid 
• 665033-14-7 4-bromo-2-(phenylethynyl)aniline 
• 869486-64-6 N-(4-bromo-2-iodophenyl)methylamine 
• 83515-06-4 5-bromo-2-phenylindole 
• 878133-05-2 N-(4-bromo-2-iodophenyl)-2,2,2-trifluoroacetamide 
• 210345-56-5 5-bromo-1H-indole-2-carboxylic acid methyl ester 
• 112671-47-3 ethyl (4-bromo-2-iodophenyl)carbamate 
• 791614-84-1 4-bromo-2-[4-(2-methyl-pyrrolidin-1-yl)-but-1-ynyl]-phenylamine 
• 912971-32-5 4-bromo-2-(2-(2-methoxyphenyl)ethynyl)aniline 
• 562080-15-3 N-(4-Bromo-2-iodo-phenyl)-4-trifluoromethoxy-benzamide 

Relevant articles and documents

CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS

The present invention provides a compound of Formula (I): an enantiomer, diastereoisomer, atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, that inhibits voltage-gated sodium channels, in particular NaV1.7. The compoun

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

A novel DMSO-assisted regioselective iodination of aniline analogues

A metal- and oxidant-free electrophilic iodination of aniline analogues was achieved in high to excellent yields at room temperature in MTBE with 0 or 3.5 equivalents of DMSO. Examined substituents include N-alkyl, N,N-dialkyl, N-morpholinyl and N-piperazinyl as well as methyl, Br, CN and CO2CH3 aryl ring substitutions.