8-deazafolic acid

Base Information

• Chemical Name: 8-deazafolic acid
• CAS No.: 51989-25-4
• Molecular Formula: C20H20 N6 O6
• Molecular Weight: 440.41
• Mol file: 51989-25-4.mol

Synonyms:L-Glutamicacid, N-[4-[[(2-amino-1,4-dihydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-(9CI); Pyrido[3,2-d]pyrimidine, L-glutamic acid deriv.; 8-Deazafolic acid; NSC173522

Chemical Property of 8-deazafolic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 200.65000
• Density: 1.61g/cm³
• LogP: 2.01760

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-deazafolic acid

There total 16 articles about 8-deazafolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Diethyl 8-Deazafolic Acid (76807-65-3) → 8-Deazafolic Acid (51989-25-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 48h; Ambient temperature;

DOI:10.1021/jo00322a004

Reference yield:

(S)-2-{4-[(2-Acetylamino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (78711-39-4) → 8-Deazafolic Acid (51989-25-4)

Guidance literature:

With sodium hydroxide; at 50 ℃; for 1h;

DOI:10.1021/jm00142a025

Reference yield:

2,4-dichloropyrido<3,2-d>pyrimidine (30212-52-3) → 8-Deazafolic Acid (51989-25-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 72 percent / 1 N aq. NaOH / 5 h / Ambient temperature

2: 75 percent / ammonia / ethanol / 18 h / 135 °C

3: 10.0 g / concd. sulfuric acid / 4 h / 125 °C

4: 18.7 percent / Br₂ / acetic acid / 4 h / 95 °C

5: dimethylsulfoxide / 22 h / Ambient temperature

6: 1 N aq. NaOH / 1 h / 50 °C

With sodium hydroxide; sulfuric acid; ammonia; bromine; In ethanol; acetic acid; dimethyl sulfoxide;

DOI:10.1021/jm00142a025

upstream raw materials:

Diethyl 8-Deazafolic Acid

(S)-2-{4-[(2-Acetylamino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

2,4-dichloropyrido<3,2-d>pyrimidine

2-amino-6-methyl-4-(3H)-pyrido<3,2-d>pyrimidinone