Technology Process of Diethyl 8-Deazafolic Acid
There total 8 articles about Diethyl 8-Deazafolic Acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 83 percent / m-Chloroperoxybenzoic acid / acetic acid / 3 h / Heating
2: 85 percent / acetic acid / 0.5 h / Heating
3: 62 percent / POCl3, (C2H5)3N / 8 h / Heating
4: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
5: 81 percent / 1 N NaOH / 10 h / Heating
6: PBr3 / tetrahydrofuran / 12 h
7: N,N-dimethyl-acetamide / 72 h / Ambient temperature
With
sodium hydroxide; ammonia; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl acetamide; acetic acid;
DOI:10.1021/jo00322a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / acetic acid / 0.5 h / Heating
2: 62 percent / POCl3, (C2H5)3N / 8 h / Heating
3: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
4: 81 percent / 1 N NaOH / 10 h / Heating
5: PBr3 / tetrahydrofuran / 12 h
6: N,N-dimethyl-acetamide / 72 h / Ambient temperature
With
sodium hydroxide; ammonia; phosphorus tribromide; triethylamine; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl acetamide; acetic acid;
DOI:10.1021/jo00322a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / liquid NH3 / 18 h / 160 - 170 °C
2: 81 percent / 1 N NaOH / 10 h / Heating
3: PBr3 / tetrahydrofuran / 12 h
4: N,N-dimethyl-acetamide / 72 h / Ambient temperature
With
sodium hydroxide; ammonia; phosphorus tribromide;
In
tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1021/jo00322a004
