2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid, 10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6- dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)-

Base Information

Chemical Name:2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid, 10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6- dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)-
CAS No.:398476-16-9
Molecular Formula:C29H40N2O9
Molecular Weight:560.645
Hs Code.:

2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid,
10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6-
dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)-

Synonyms:

Suppliers and Price of 2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid, 10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6- dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid, 10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6- dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid, 10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6- dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)-

There total 7 articles about 2,7-Diazaspiro[4.5]decane-2,3-dicarboxylic acid, 10-[2-(1,1-dimethylethoxy)-2-oxoethyl]-7-[(4-methoxyphenyl)methyl]-1,6- dioxo-, 2-(1,1-dimethylethyl) 3-methyl ester, (3R,5R,10S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 398476-15-8
(3rac, 5R)-1-(tert-butoxycarbonyl)-3-{[(N-tert-butoxycarbonyl)-N-(4-methoxybenzyl)but-3-yn-1-yl]carbamoyl}-2-pyrrolidinon-5-carboxylic methyl ester

: 398476-16-9
(3R, 5R, 10R)-10-(tert-butoxycarbonylmethyl)-7-(4-methoxybenzyl)-1,6-dioxa-2,7-diaza-spiro[4,5]decane-2,3-dicarboxylic 2-tert-butyl ester 3-methyl ester

Guidance literature:: (3rac, 5R)-1-(tert-butoxycarbonyl)-3-{[(N-tert-butoxycarbonyl)-N-(4-methoxybenzyl)but-3-yn-1-yl]carbamoyl}-2-pyrrolidinon-5-carboxylic methyl ester; With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 16h; Heating;

With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 760 Torr;
DOI:10.1002/1521-3765(20011119)7:22<4811::AID-CHEM4811>3.0.CO;2-P

Reference yield:

: 128811-48-3
1‐(tert‐butyl) 2‐methyl (R)‐5‐oxopyrrolidine‐1,2‐dicarboxylate

: 398476-16-9
(3R, 5R, 10R)-10-(tert-butoxycarbonylmethyl)-7-(4-methoxybenzyl)-1,6-dioxa-2,7-diaza-spiro[4,5]decane-2,3-dicarboxylic 2-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 95 percent / tetrahydrofuran / -78 °C

2.1: 73 percent / AgOTf; (iPr)2NEt / acetonitrile / 14 h / 20 °C

3.1: (iPr)2NEt / acetonitrile / 16 h / Heating

3.2: 80 percent / H₂ / 10 percent Pd/C / methanol / 16 h / 760 Torr

With silver trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1002/1521-3765(20011119)7:22<4811::AID-CHEM4811>3.0.CO;2-P

Reference yield:

: 146980-79-2
N-(4-methoxybenzyl)-4-amino-1-butyne

: 398476-16-9
(3R, 5R, 10R)-10-(tert-butoxycarbonylmethyl)-7-(4-methoxybenzyl)-1,6-dioxa-2,7-diaza-spiro[4,5]decane-2,3-dicarboxylic 2-tert-butyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 86 percent / DMAP; NEt₃ / CH₂Cl₂ / 72 h / 20 °C

2.1: nBuLi / diethyl ether; hexane / 0.5 h / -78 °C

2.2: 96 percent / diethyl ether; hexane / 1.25 h / -78 - 20 °C

3.1: 73 percent / pTsOH*H₂O / 2-methyl-propan-2-ol; diethyl ether / 16 h / 20 °C

4.1: 73 percent / AgOTf; (iPr)2NEt / acetonitrile / 14 h / 20 °C

5.1: (iPr)2NEt / acetonitrile / 16 h / Heating

5.2: 80 percent / H₂ / 10 percent Pd/C / methanol / 16 h / 760 Torr

With dmap; n-butyllithium; silver trifluoromethanesulfonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1002/1521-3765(20011119)7:22<4811::AID-CHEM4811>3.0.CO;2-P