Phenyl(dichloromethyl) sulfone

Base Information

• Chemical Name: Phenyl(dichloromethyl) sulfone
• CAS No.: 31540-74-6
• Molecular Formula: C7H6 Cl2 O2 S
• Molecular Weight: 225.095
• Hs Code.: 2904909090
• Mol file: 31540-74-6.mol

Synonyms:Sulfone,dichloromethyl phenyl (8CI); Dichloromethyl phenyl sulfone; NSC 170765; Phenyldichloromethyl sulfone

Chemical Property of Phenyl(dichloromethyl) sulfone

Chemical Property:

• Vapor Pressure: 0.000159mmHg at 25°C
• Boiling Point: 341.4°C at 760 mmHg
• Flash Point: 160.3°C
• PSA: 42.52000
• Density: 1.458g/cm³
• LogP: 3.30230

Purity/Quality:

99% ^*data from raw suppliers

(Dichloro-methanesulfonyl)-benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenyl(dichloromethyl) sulfone

There total 15 articles about Phenyl(dichloromethyl) sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-benzenesulfonyl-2,2-dichloro-1-phenyl-ethanone (861524-26-7) → dichloromethyl phenyl sulfone (31540-74-6)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2006.11.129

Reference yield: 77.0%

2,2-dichloro-1-methyl-2-phenylsulfonylethanone (90476-27-0) → dichloromethyl phenyl sulfone (31540-74-6)

Guidance literature:

With alkali; In water;

Reference yield: 60.0%

trichloromethyl methyl sulfone (42764-08-9) → dichloromethyl phenyl sulfone (31540-74-6)

Guidance literature:

With iron(II) chloride; In acetonitrile; at 80 ℃; for 24h;

upstream raw materials:

phenyl dichloromethyl thioether

benzenesulfonylacetic acid

2-(phenylsulfonyl)acetonitrile

chloroform

Downstream raw materials:

α-Chloro-4-nitrobenzyl phenyl sulfone

(E)-1,1-dichloro-4-phenyl-1-(phenylsulfonyl)but-3-en-2-ol

(1,1-dichloro-3-nitro-2-phenylpropylsulfonyl)benzene

3-[dichloro(phenylsulfonyl)methyl]cyclohexanone

Refernces

• 1、 Suryakiran,Prabhakar,Srikanth Reddy,Chinni Mahesh,Rajesh,Venkateswarlu. "Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones". . p. 877 - 881. Retrieved 2007/10/03.
• 2、 Itoh, Takashi,Matsuya, Yuji,Nagata, Kazuhiro,Okada, Mamiko,Ohsawa, Akio. "A Regiospecific Reaction of Pyridazines with Vicarious Nucleophilic Substitution via Their Dicyanomethylide Derivatives". . p. 2067 - 2068. Retrieved 2007/10/02.