6-AMINO-3H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 6-AMINO-3H-QUINAZOLIN-4-ONE
• CAS No.: 17329-31-6
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.163
• Mol file: 17329-31-6.mol

Synonyms:4(1H)-Quinazolinone,6-amino- (9CI);6-Amino-3H-quinazolin-4-one;6-Amino-4(1H)-quinazolinone;6-Amino-4(3H)-quinazolinone;6-Amino-4-hydroxyquinazoline;6-Amino-4-quinazolinone;NSC 338202;

Chemical Property of 6-AMINO-3H-QUINAZOLIN-4-ONE

Chemical Property:

• Vapor Pressure: 2.67E-07mmHg at 25°C
• Melting Point: 303 °C(Solv: water (7732-18-5))
• Refractive Index: 1.734
• Boiling Point: 421.1 °C at 760 mmHg
• PKA: 3.95±0.20(Predicted)
• Flash Point: 208.5 °C
• PSA: 72.03000
• Density: 1.49 g/cm³
• LogP: 1.49880
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99.5% ^*data from raw suppliers

6-Amino-3H-quinazolin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AMINO-3H-QUINAZOLIN-4-ONE

There total 12 articles about 6-AMINO-3H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-nitroquinazolone (6943-17-5) → 6-amino-3H-quinazolin-4-one (17329-31-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 4h;

Reference yield: 97.0%

6-nitroquinazolin-4-ol (6943-17-5) → 6-amino-4-hydroxyquinazoline (17329-31-6)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; water; at 80 ℃; for 2.5h; Temperature; Reagent/catalyst;

Reference yield:

2-amino-5-nitro-benzoic acid (616-79-5) → 6-amino-3H-quinazolin-4-one (17329-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / 0.67 h / 150 °C / microwave irradiation

2: 90 percent / ammonium formate / Pd/C / methanol / 0.17 h / 65 °C / microwave irradiation

With ammonium formate; palladium on activated charcoal; In methanol; 1: Niementowski condensation;

DOI:10.1016/S0040-4039(03)01026-8

upstream raw materials:

6-nitroquinazolone

2-amino-5-nitro-benzoic acid

5-nitroanthranilonitrile

indole-2,3-dione

Downstream raw materials:

6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol

N-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)methyl)-2,2,2-trifluoro-N-(2-(methylsulfonyl)ethyl)acetamide

lapatinib ditosylate

Refernces

• 1、 -. "Method for synthesizing lapatinib or intermediate 5-(4-hydroxy quinazoline)-furan-2-formaldehyde of lapatinib". Paragraph 0034; 0039; 0040; 0041; 0056; 0057; 0073; 0074. . Retrieved 2017/03/22.
• 2、 -. "PROCESS FOR THE PREPARATION OF LAPATINIB". Page/Page column 12; 13. . Retrieved 2014/11/11.