di-tert-butyl 2-desamino-5,8-dideazaisofolate

Base Information

• Chemical Name: di-tert-butyl 2-desamino-5,8-dideazaisofolate
• CAS No.: 118895-90-2
• Molecular Formula: C₂₉H₃₆N₄O₆
• Molecular Weight: 536.628
• Mol file: 118895-90-2.mol

Synonyms:di-tert-butyl 2-desamino-5,8-dideazaisofolate

Chemical Property of di-tert-butyl 2-desamino-5,8-dideazaisofolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 2-desamino-5,8-dideazaisofolate

There total 3 articles about di-tert-butyl 2-desamino-5,8-dideazaisofolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

di-tert-butyl N-(4-formylbenzoyl)-L-glutamate (87597-84-0) + 6-amino-4-hydroxyquinazoline (17329-31-6) → di-tert-butyl 2-desamino-5,8-dideazaisofolate (118895-90-2)

Guidance literature:

With hydrogen; nickel; In acetic acid;

DOI:10.1021/jm00124a019

Reference yield:

6-nitroisatoic anhydride (4693-02-1) → di-tert-butyl 2-desamino-5,8-dideazaisofolate (118895-90-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / 6 h / 160 - 165 °C

2: 92 percent / H₂ / 10percent Pd-C / 2-methoxy-ethanol

3: 34 percent / H₂ / Raney Ni / aq. acetic acid

With hydrogen; palladium on activated charcoal; nickel; In 2-methoxy-ethanol; acetic acid;

DOI:10.1021/jm00124a019

Reference yield:

6-nitroquinazolin-4-ol (6943-17-5) → di-tert-butyl 2-desamino-5,8-dideazaisofolate (118895-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / 10percent Pd-C / 2-methoxy-ethanol

2: 34 percent / H₂ / Raney Ni / aq. acetic acid

With hydrogen; palladium on activated charcoal; nickel; In 2-methoxy-ethanol; acetic acid;

DOI:10.1021/jm00124a019

upstream raw materials:

di-tert-butyl N-(4-formylbenzoyl)-L-glutamate

6-amino-4-hydroxyquinazoline

6-nitroisatoic anhydride

6-nitroquinazolin-4-ol

Downstream raw materials:

2-desamino-5,8-dideazaisofolic acid

Refernces