Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp

Base Information

Chemical Name:Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp
CAS No.:134458-76-7
Molecular Formula:C₄₁H₅₉N₇O₇
Molecular Weight:761.962
Hs Code.:
DSSTox Substance ID:DTXSID60158718
Nikkaji Number:J425.787A
Wikidata:Q83027033
ChEMBL ID:CHEMBL3350192

Synonyms:Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp;134458-76-7;CHEMBL3350192;L-Idonamide, 2,5,6-trideoxy-5-((3-(1H-imidazol-4-yl)-2-(((1-naphthalenyloxy)acetyl)amino)-1-oxopropyl)amino)-N-(2-methyl-1-(((2-pyridinylmethyl)amino)carbonyl)butyl)-6-phenyl-2-(phenylmethyl)-, (1(1S,2S),5(S))-;L-Idonamide, 2,5,6-trideoxy-5-[[3-(1H-imidazol-4-yl)-2-[[(1-naphthalenyloxy)acetyl]amino]-1-oxopropyl]amino]-N-[2-methyl-1-[[(2-pyridinylmethyl)amino]carbonyl]butyl]-6-phenyl-2-(phenylmethyl)-, [1(1S,2S),5(S)]-;DTXSID60158718;BDBM50229416;Poa-His-Cha-.psi.[CH(OH)CH(OH)]-Val-Ile-Amp;(2R,3R,4R,5S)-6-cyclohexyl-3,4-dihydroxy-5-[[(2S)-3-(1H-imidazol-4-yl)-2-[(2-phenoxyacetyl)amino]propanoyl]amino]-2-isopropyl-N-[(1S,2S)-2-methyl-1-(2-pyridylmethylcarbamoyl)butyl]hexanamide

Suppliers and Price of Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:1112.2°Cat760mmHg
Flash Point:626.4°C
Density:1.201g/cm³
XLogP3:4.8
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:21
Exact Mass:761.44759725
Heavy Atom Count:55
Complexity:1180

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C(C(=O)NCC1=CC=CC=N1)NC(=O)C(C(C)C)C(C(C(CC2CCCCC2)NC(=O)C(CC3=CN=CN3)NC(=O)COC4=CC=CC=C4)O)O
Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)NCC1=CC=CC=N1)NC(=O)[C@@H]([C@H]([C@@H]([C@H](CC2CCCCC2)NC(=O)[C@H](CC3=CN=CN3)NC(=O)COC4=CC=CC=C4)O)O)C(C)C

Technology Process of Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp

There total 8 articles about Poa-His-Cha-psi(CH(OH)CH(OH))-Val-Ile-Amp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(S)-2-((1S,2R,3R,4R)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexylcarbamoyl)-2-(2-phenoxy-acetylamino)-ethyl]-imidazole-1-carboxylic acid tert-butyl ester

: 134458-76-7
(2R,3R,4R,5S)-6-Cyclohexyl-3,4-dihydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.25h;
DOI:10.1021/jm00112a005

Reference yield:

: 117997-58-7
tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate

: 134458-76-7
(2R,3R,4R,5S)-6-Cyclohexyl-3,4-dihydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: Multi-step reaction with 7 steps

3: 98 percent / periodic acid, ruthenium trichloride hydrate / acetonitrile; CCl₄; H₂O / 2 h

4: diisopropylethylamine, diethylphosphoryl cyanide / CH₂Cl₂ / 14 h / Ambient temperature

5: acetyl chloride, ethanedithiol / methanol / 5 h

6: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 14 h

7: trifluoroacetic acid / CH₂Cl₂ / 0.25 h

With ethandithiol; ruthenium trichloride; diethylphosphoryl cyanide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; periodic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; trifluoroacetic acid; In methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00112a005

Reference yield:

: 107599-99-5
(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone

: 134458-76-7
(2R,3R,4R,5S)-6-Cyclohexyl-3,4-dihydroxy-5-[(S)-3-(1H-imidazol-4-yl)-2-(2-phenoxy-acetylamino)-propionylamino]-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: Multi-step reaction with 7 steps

3: 98 percent / periodic acid, ruthenium trichloride hydrate / acetonitrile; CCl₄; H₂O / 2 h

4: diisopropylethylamine, diethylphosphoryl cyanide / CH₂Cl₂ / 14 h / Ambient temperature

5: acetyl chloride, ethanedithiol / methanol / 5 h

6: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 14 h

7: trifluoroacetic acid / CH₂Cl₂ / 0.25 h

With ethandithiol; ruthenium trichloride; diethylphosphoryl cyanide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; periodic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; trifluoroacetic acid; In methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00112a005