Orphenadrine citrate

Base Information

• Chemical Name: Orphenadrine citrate
• CAS No.: 4682-36-4
• Deprecated CAS: 4596-23-0
• Molecular Formula: C18H23NO^.C6H8O7
• Molecular Weight: 461.512
• Hs Code.: 2922190900
• European Community (EC) Number: 225-137-5
• NSC Number: 757238
• UNII: X0A40N8I4S
• DSSTox Substance ID: DTXSID8044678
• Wikidata: Q27107584
• NCI Thesaurus Code: C47641
• RXCUI: 7716
• ChEMBL ID: CHEMBL1200395
• Mol file: 4682-36-4.mol

Synonyms:Citrate, Norflex Orphenadrine;Citrate, Orphenadrine;Disipal;Hydrochloride, Orphenadrine;Lysantin;Mefenamine;Mefenamine, Sodium;Mephenamine;Methyldiphenylhydramine;Norflex;Norflex Orphenadrine Citrate;Orphenadrine;Orphenadrine Citrate;Orphenadrine Citrate, Norflex;Orphenadrine Hydrochloride;Sodium Mefenamine

Chemical Property of Orphenadrine citrate

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 1.86E-05mmHg at 25°C
• Melting Point: 132-134 °C
• Boiling Point: 363 °C at 760 mmHg
• Flash Point: 107.1 °C
• PSA: 133.60000
• Density: 1.014 g/cm3
• LogP: 2.75980
• Storage Temp.: 2-8°C
• Solubility.: Sparingly soluble in water, slightly soluble in ethanol (96 per cent).
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 11
• Exact Mass: 461.20496695
• Heavy Atom Count: 33
• Complexity: 488

Purity/Quality:

99%, ^*data from raw suppliers

Orphenadrine citrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-40-20/21/22
• Safety Statements: 22-36-62-38-36/37/39-28-26-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• Recent EU Clinical Trials: Neodolpasse? Infusion Solution versus diclofenac 75 mg infusion in the treatment of postoperative pain after elective knee surgery - an exploratory placebo-controlled clinical study to investigate the analgesic properties of the combination of diclofenac and orphenadrine versus diclofenac alone.
• Uses: Muscle relaxant (skeletal); antihistaminic skeletal muscle relaxant, antihistaminic agent A histaminergic compound
• Therapeutic Function: Muscle relaxant
• Clinical Use: Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.

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