Technology Process of 1-(2-pyridinyl)-Cyclopentanecarbonitrile
There total 1 articles about 1-(2-pyridinyl)-Cyclopentanecarbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
diethyl ether; dimethyl sulfoxide; mineral oil;
at 15 - 20 ℃;
for 25h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: water; hydrogenchloride / 16 h / 80 °C / Sealed tube
2: borane-THF / tetrahydrofuran / 6 h / 0 - 20 °C
3: triethylamine / dichloromethane / 2 h / 0 - 20 °C
4: potassium iodide / dimethyl sulfoxide / 5 h / 140 °C
5: ammonium chloride; trimethylaluminum / toluene / 14 h / 5 - 100 °C
6: sodium methylate / methanol / 16 h / 0 - 20 °C
With
hydrogenchloride; borane-THF; water; trimethylaluminum; sodium methylate; ammonium chloride; triethylamine; potassium iodide;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: water; hydrogenchloride / 16 h / 80 °C / Sealed tube
2: borane-THF / tetrahydrofuran / 6 h / 0 - 20 °C
3: triethylamine / dichloromethane / 2 h / 0 - 20 °C
4: potassium iodide / dimethyl sulfoxide / 5 h / 140 °C
5: ammonium chloride; trimethylaluminum / toluene / 14 h / 5 - 100 °C
6: sodium methylate / methanol / 16 h / 0 - 20 °C
7: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux
With
hydrogenchloride; borane-THF; lithium hydroxide monohydrate; water; trimethylaluminum; sodium methylate; ammonium chloride; triethylamine; potassium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
