6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde

Base Information

• Chemical Name: 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde
• CAS No.: 400777-11-9
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Hs Code.: 2933990090
• European Community (EC) Number: 642-023-4
• UNII: L5SS4WH9HH
• Nikkaji Number: J2.961.694I
• Mol file: 400777-11-9.mol

Synonyms:400777-11-9;6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde;ZOLPIDEM CARBALDEHYDE;6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridine-3-carbaldehyde;L5SS4WH9HH;Zolpaldehyde;MFCD04117108;6-Methyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-carboxaldehyde;6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carboxaldehyde;Imidazo(1,2-a)pyridine-3-carboxaldehyde, 6-methyl-2-(4-methylphenyl)-;Imidazo[1,2-a]pyridine-3-carboxaldehyde, 6-methyl-2-(4-methylphenyl)-;Zolpaldehyde (6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carboxaldehyde);UNII-L5SS4WH9HH;SCHEMBL2228417;STK504150;AKOS000266552;NS-03718;BB 0260505;2-(4-Methylphenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property of 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property:

• Melting Point: 151-153°C
• PKA: 4.42±0.50(Predicted)
• PSA: 34.37000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 3.43060
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 250.110613074
• Heavy Atom Count: 19
• Complexity: 325

Purity/Quality:

98%min ^*data from raw suppliers

ZolpidemCarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)C=O
• Uses: An impurity of Zolpidem (Z650000).

Technology Process of 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde

There total 9 articles about 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bis(trichloromethyl) carbonate (32315-10-9) + 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridine-3-carbaldehyde (400777-11-9)

Guidance literature:

bis(trichloromethyl) carbonate; N,N-dimethyl-formamide; In toluene; at 5 - 25 ℃; for 1h;

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine; In N,N-dimethyl-formamide; toluene; at 100 ℃; for 3h; Concentration; Temperature; Solvent;

Reference yield: 88.0%

N-formyldiethylamine (617-84-5) + bis(trichloromethyl) carbonate (32315-10-9) + 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8) → 6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridine-3-carbaldehyde (400777-11-9)

Guidance literature:

N-formyldiethylamine; bis(trichloromethyl) carbonate; In toluene; at 5 - 25 ℃; for 1h;

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine; In N,N-dimethyl-formamide; toluene; at 100 ℃; for 3h;

Reference yield: 81.0%

bis(trichloromethyl) carbonate (32315-10-9) + diphenylformamide (607-00-1) + 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8) → 6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridine-3-carbaldehyde (400777-11-9)

Guidance literature:

bis(trichloromethyl) carbonate; diphenylformamide; In toluene; at 5 - 25 ℃; for 1h;

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine; In N,N-dimethyl-formamide; toluene; at 100 ℃; for 3h;

upstream raw materials:

6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine

N,N-dimethyl-formamide

(5-methyl-pyridin-2-yl)amine

5-methyl-N-(1-(p-tolyl)allyl)-2-aminopyridine

Downstream raw materials:

(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanol

3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine

N-((6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine

1-methyl-3-((6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)methyl)imidazolidin-2-one

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