607-00-1

Basic information

• Product Name: N,N-DIPHENYLFORMAMIDE
• Synonyms: LABOTEST-BB LT00053344;FORMYLDIPHENYLAMINE;DPF;N,N-DIPHENYLFORMAMIDE, LIQUID PHASE FOR GC;Formamide, N,N-diphenyl-;N,N-diphenylfomamide;N,N-di(phenyl)methanamide;N,N-Diphenylformamide
• CAS NO: 607-00-1
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.23
• EINECS: 210-129-6
• Product Categories: AmidesGas Chromatography;Packed GC;Stationary Phases;Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 607-00-1.mol
• Article Data: 88

Chemical Properties

• Melting Point: 69-73 °C(lit.)
• Boiling Point: 337 °C762 mm Hg(lit.)
• Flash Point: 155.6°C
• Appearance: /
• Density: 1.1012 (rough estimate)
• Vapor Pressure: 0.000105mmHg at 25°C
• Refractive Index: 1.6050 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.73±0.50(Predicted)
• BRN: 2209397
• CAS DataBase Reference: N,N-DIPHENYLFORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIPHENYLFORMAMIDE(607-00-1)
• EPA Substance Registry System: N,N-DIPHENYLFORMAMIDE(607-00-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 607-00-1(Hazardous Substances Data)

Usage

General Description

N,N-Diphenylformamide is a chemical compound composed of a formamide group and two phenyl groups. It is often used as a precursor in the synthesis of various pharmaceuticals, dyes, and other organic compounds. It is also known to have some industrial applications in the production of plastics and polymers. N,N-Diphenylformamide is a white to light yellow crystalline solid with a faint odor, and it is sparingly soluble in water but more soluble in organic solvents. N,N-DIPHENYLFORMAMIDE may cause skin and eye irritation and is considered harmful if ingested or inhaled in large amounts. Therefore, proper safety measures should be taken when handling this chemical.

InChI:InChI=1/C13H11NO/c15-11-14(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11H

Upstream product

• 144-62-7 oxalic acid 
• 122-39-4 diphenylamine 
• 591-50-4 iodobenzene 
• 78-90-0 1,2-diaminopropan 
• 103-70-8 Formanilid 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 109-94-4 formic acid ethyl ester 
• 780-25-6 N-benzylidene benzylamine 
• 667-27-6 Ethyl bromodifluoroacetate 
• 4282-80-8 N-phenyl-N-propargylaniline 
• 552-82-9 benzhydrylidene(methyl)amine 
• 67-56-1 methanol 
• 2875-79-8 N,N-diphenylimidazole-1-carboxamide 
• 1988-22-3 4-chlorophenyl formate 

Downstream Products

• 122-39-4 diphenylamine 
• 590-86-3 isovaleraldehyde 
• 91-01-0 1,1-Diphenylmethanol 
• 100-52-7 benzaldehyde 
• 102449-66-1 diphenylaminomethylene-succinic acid diethyl ester 
• 3147-03-3 N,N-diphenyl-N'-phenylsulfonylformamidine 
• 85218-53-7 N'-Benzothiazol-2-yl-N,N-diphenyl-formamidine 
• 890534-61-9 N,N-diphenylaminocyclopropane 
• 62424-28-6 trans-SnBr₄(DPF)2 
• 1372426-42-0 (C₂H₅)3SiOGe(C₄H₉)2OSi(C₂H₅)3 
• 3124-24-1 trimeres Di-n-butyl-germaniumoxid 
• 1313865-80-3 1-phenyl-3,4-dipropylquinolin-2(1H)-one 
• 57834-44-3 N,N-Diphenyl-N'-(4-ethoxycarbonylphenyl)formamidine 
• 64-18-6 formic acid 

Relevant articles and documents

Preparation and catalytic evaluation of a palladium catalyst deposited over modified clinoptilolite (Pd&at;MCP) for chemoselective N-formylation and N-acylation of amines

Novel palladium nanoparticles stabilized by clinoptilolite as a natural inexpensive zeolite prepared and used for N-formylation and N-acylation of amines at room temperature at environmentally benign reaction conditions in good to excellent yields. Pd (II) was immobilized on the surface of clinoptilolite via facile multi-step amine functionalization to obtain a sustainable, recoverable, and highly active nano-catalyst. The structural and morphological characterizations of the catalyst carried out using XRD, FT-IR, BET and TEM techniques. Moreover, the catalyst is easily recovered using simple filtration and reused for 7 consecutive runs without any loss in activity.

Selective N-formylation of amines catalysed by Ag NPs festooned over amine functionalized SBA-15 utilizing CO2 as C1 source

N-formylation of amines using CO2 as C1 source has been an uphill transformation in the catalysis research as it involves the utilization of abundant thermodyanamically stable and kinetically inert CO2 to form the N-formylated products, which are potential intermediates for the synthesis of valuable chemicals. Previously various noble as well as non-noble metal nanoparticles have been employed for N-formylation of amines. However, herein for the first time we explored N-formylation reaction under lenient conditions utilizing silver nanoparticles, which are decorated over amine functionalized periodically ordered 2D-hexagonal SBA-15 material, serving as a robust heterogeneous catalyst. The AgNPs@SBA-15-NH2 has been intensively characterized by powder XRD, Brunauer-Emmett-Teller (BET), FEG-TEM, SEM, XPS, TGA, CO2-TPD, FTIR and UV–vis spectroscopic analyses. This supported AgNPs material showed remarkable catalytic activity for N-formylation over a wide range of amines under 0.5 MPa CO2 pressure and at mild temperature (35 °C) conditions. In addition, this AgNPs@SBA-15-NH2 material exhibited high chemical stability and reusability, suggesting its promising future in the CO2 fixation reactions.

Direct Synthesis of N,N-Disubstituted Formamides by Oxidation of Imines Using an HFIP/UHP System

The straightforward synthesis of N,N-disubstituted formamides using a combination of 1,1,1,3,3,3-hexafluoroispropanol (HFIP) and H2O2 is described. The unique features of HFIP allowed the utilization of a green oxidant such as H2O2, and the products, arising from an oxidation-rearrangement sequence, were obtained in good to high yields under smooth reaction conditions.