5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-1-(3-hydroxypropyl)-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-1-(3-hydroxypropyl)-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester
CAS No.:400797-87-7
Molecular Formula:C21H26F3N3O3
Molecular Weight:425.451
Hs Code.:

5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid,
1,4,6,7-tetrahydro-1-(3-hydroxypropyl)-3-[4-(trifluoromethyl)phenyl]-,
1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-1-(3-hydroxypropyl)-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester

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Technology Process of 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-1-(3-hydroxypropyl)-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester

There total 3 articles about 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-1-(3-hydroxypropyl)-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 400797-86-6
1-(2-methoxycarbonyl-ethyl)-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

: 400797-87-7
1-(3-Hydroxy-propyl)-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

Guidance literature:: With lithium borohydride; In tetrahydrofuran;

Reference yield:

: 400797-84-4
3-(4-Trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

: 627-18-9
1-bromo-3-propanol

: 400797-87-7
1-(3-Hydroxy-propyl)-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2006.01.038

Reference yield:

: 400797-84-4
3-(4-Trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

: 400797-87-7
1-(3-Hydroxy-propyl)-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / toluene

2: lithium borohydride / tetrahydrofuran

With lithium borohydride; sodium t-butanolate; In tetrahydrofuran; toluene;