4,6-Isoquinolinediol,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(1S,4S)-

Base Information

Chemical Name:4,6-Isoquinolinediol,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(1S,4S)-
CAS No.:102865-31-6
Molecular Formula:C20H25 N O5
Molecular Weight:359.422
Hs Code.:

Synonyms:4,6-Isoquinolinediol,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(1S-trans)-; (+)-Roemecarine; Roemecarine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,6-Isoquinolinediol,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(1S,4S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4,6-Isoquinolinediol,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(1S,4S)-

There total 4 articles about 4,6-Isoquinolinediol,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(1S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 51724-64-2,96012-98-5,96109-08-9,125993-69-3,134780-53-3
(+/-)-1,4-trans-4-acetoxy-1-(3,4-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 102865-31-6,113216-30-1,113216-31-2,134780-54-4
(+/-)-Roemecarine

Guidance literature:: With potassium hydroxide; In methanol; for 6h; Ambient temperature;
DOI:10.3987/R-1987-08-2099

Reference yield: 59.0%

: 51724-64-2,96012-98-5,96109-08-9,125993-69-3,134780-53-3
(+/-)-1,4-cis-4-acetoxy-1-(3,4-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 102865-31-6,113216-30-1,113216-31-2,134780-54-4
(+/-)-Epiroemecarine

Guidance literature:: With potassium hydroxide; In methanol; for 4h; Ambient temperature;
DOI:10.1248/cpb.38.3277

Reference yield:

: 51724-64-2,96012-98-5,96109-08-9,125993-69-3,134780-53-3
(+/-)-1,4-trans-4-acetoxy-1-(3,4-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 102865-31-6
(+)-Roemecarine

: 134780-54-4
(-)-Roemecarine

: 51724-64-2,96012-98-5,96109-08-9,125993-69-3,134780-53-3
Acetic acid (1S,4S)-1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl ester

Guidance literature:: With water; In 2,2,4-trimethylpentane; benzene; at 33 ℃; for 72h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; OF-360 lipase immobilized on Celite 535;
DOI:10.1248/cpb.38.3277