Technology Process of (S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline
There total 8 articles about (S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol; acetic acid;
under 2585.7 Torr;
Ambient temperature;
DOI:10.1016/S0040-4020(01)87686-9
- Guidance literature:
-
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
1,4-dioxane;
for 6h;
under 1551.4 Torr;
Ambient temperature;
DOI:10.1248/cpb.38.3277
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / formic acid / 24 h / 40 °C
2: 91 percent / toluene / 16 °C / Heating
3: 1) t-butyllithium / 1) THF, pentane, -100 deg C, 0.5 h, 2) THF, pentane, -100 deg C, 0.5 h
4: hidrazine / aq. ethanol; acetic acid / 50 °C
5: 2.) NaBH4 / 1) MeOH, RT, 0.2 h, 2) MeOH, 1 h
6: 90 percent / hydrogen / 4percent Pd/C / methanol; acetic acid / 2585.7 Torr / Ambient temperature
With
sodium tetrahydroborate; formic acid; hydrogen; tert.-butyl lithium; hydrazine;
palladium on activated charcoal;
In
methanol; ethanol; acetic acid; toluene;
DOI:10.1016/S0040-4020(01)87686-9
