(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

Base Information

Chemical Name:(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline
CAS No.:13452-22-7
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:

Synonyms:(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

Suppliers and Price of (S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

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Technology Process of (S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

There total 8 articles about (S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 116262-26-1
(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-benzyloxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

: 13452-22-7
(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; under 2585.7 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)87686-9

Reference yield: 86.9%

: 102865-31-6
(+)-Roemecarine

: 13452-22-7
(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 6h; under 1551.4 Torr; Ambient temperature;
DOI:10.1248/cpb.38.3277

Reference yield:

: 36455-21-7
3-benzyloxy-4-methoxyphenylethylamine

: 13452-22-7
(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / formic acid / 24 h / 40 °C

2: 91 percent / toluene / 16 °C / Heating

3: 1) t-butyllithium / 1) THF, pentane, -100 deg C, 0.5 h, 2) THF, pentane, -100 deg C, 0.5 h

4: hidrazine / aq. ethanol; acetic acid / 50 °C

5: 2.) NaBH₄ / 1) MeOH, RT, 0.2 h, 2) MeOH, 1 h

6: 90 percent / hydrogen / 4percent Pd/C / methanol; acetic acid / 2585.7 Torr / Ambient temperature

With sodium tetrahydroborate; formic acid; hydrogen; tert.-butyl lithium; hydrazine; palladium on activated charcoal; In methanol; ethanol; acetic acid; toluene;
DOI:10.1016/S0040-4020(01)87686-9