Dodecahydro-4H,8H,12H-4a,8a,12a-triazatriphenylene

Base Information

• Chemical Name: Dodecahydro-4H,8H,12H-4a,8a,12a-triazatriphenylene
• CAS No.: 522-33-8
• Molecular Formula: C₁₅H₂₇N₃
• Molecular Weight: 249.399
• Hs Code.: 2933998090
• Mol file: 522-33-8.mol

Synonyms:trimer of 2,3,4,5-tetrahydropyridine;a-Tripiperideine;1-piperidine trimer;dodecahydro-4a,8a,12a-triazatriphenylene;Alpha-Tripiperideine;Dodecahydro-4H,8H,12H-4a,8a,12a-triazatriphenylene;2,3,4,5-tetrahydropyridine trimer;trimer of 1,2-didehydropiperidine;

Chemical Property of Dodecahydro-4H,8H,12H-4a,8a,12a-triazatriphenylene

Chemical Property:

• Boiling Point: 354.9°Cat760mmHg
• Flash Point: 177.4°C
• PSA: 9.72000
• Density: 1.12g/cm³
• LogP: 2.24970
• Solubility.: Dichloromethane

Purity/Quality:

97% ^*data from raw suppliers

α-Tripiperideine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α-Tripiperideine (cas# 522-33-8) is a compound useful in organic synthesis.

Technology Process of Dodecahydro-4H,8H,12H-4a,8a,12a-triazatriphenylene

There total 6 articles about Dodecahydro-4H,8H,12H-4a,8a,12a-triazatriphenylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

piperidine (110-89-4) + N-chloropiperidine (2156-71-0) → Tripiperidin (522-33-8,2583-71-3,60537-08-8) + 2,3,4,5-tetrahydropyridine (505-18-0)

Guidance literature:

piperidine; With N-chloro-succinimide; In tert-butyl methyl ether; water; at 0 - 15 ℃; for 0.583333h; Inert atmosphere;

N-chloropiperidine; With potassium tert-butylate; In methanol; at 15 - 40 ℃; for 1.83333h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03253

Reference yield: 6.0%

1-(prop-2-yn-1-yl)piperidine (5799-75-7) → Tripiperidin (522-33-8,2583-71-3,60537-08-8) + 5,6,7,8-tetrahydropyrrolo<1,2-a>pyridine (13618-88-7) + 1,2-propanediene (463-49-0)

Guidance literature:

at 450 ℃; under 24 Torr; Product distribution; Mechanism; other temperatures and pressures;

DOI:10.1021/jo00071a015

Reference yield:

N,N'-bis(piperidino)diazene (2081-14-3) → Tripiperidin (522-33-8,2583-71-3,60537-08-8) + piperidine (110-89-4) + 1-(piperidin-1-yl)piperidine (6130-94-5) + N-Formylpiperidine (2591-86-8) + 2-piperidinotetrahydrofuran (99705-97-2)

Guidance literature:

In tetrahydrofuran; at 30 ℃; Product distribution; Irradiation;

DOI:10.1021/jo00353a018

upstream raw materials:

(E)-1-(phenyldiazenyl)piperidine

N-chloropiperidine

2,3,4,5-tetrahydropyridine

1-(prop-2-yn-1-yl)piperidine

Downstream raw materials:

isopelletierine

1-phenyl-2-(piperidin-2-yl)ethan-1-one

1-(3,4-dihydro-2H-pyridin-1-yl)ethanone

(+/-)-(4ar,4bt,9at,14at)-tetradecahydro-tripyrido[1,2-a;1',2'-c;3'',2''-e]pyrimidine