1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one

Base Information

Chemical Name:1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one
CAS No.:401792-02-7
Molecular Formula:C15H18N2O2
Molecular Weight:258.32
Hs Code.:
European Community (EC) Number:849-578-3
Nikkaji Number:J3.385.594J
Mol file:401792-02-7.mol

Synonyms:401792-02-7;4(1H)-Pyridinone, 2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-;2-(aminomethyl)-3-(benzyloxy)-1,6-dimethyl-1,4-dihydropyridin-4-one;1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one;2-(aminomethyl)-3-(benzyloxy)-1,6-dimethylpyridin-4(1H)-one;2-(aminomethyl)-1,6-dimethyl-3-phenylmethoxypyridin-4-one;SCHEMBL15020503;YWDKTOKVJMCHGW-UHFFFAOYSA-N;BRA79202;MFCD14551484;AKOS022288013;NS-03967;D94325;EN300-7547284;1,6-dimethyl-2-aminomethyl-3-benzyloxy-4-pyridinone;Z2049898296;1,6-Dimethyl-2-(aminomethyl)-3-benzyloxy-1,4-dihydropyridine-4-one

Suppliers and Price of 1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of 1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:258.136827821
Heavy Atom Count:19
Complexity:406

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=O)C(=C(N1C)CN)OCC2=CC=CC=C2

Technology Process of 1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one

There total 10 articles about 1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 401792-01-6
2-((3-(benzyloxy)-1,6-dimethyl-4-oxo-1,4-dihydropyridin-2-yl)methyl)iso-indoline-1,3-dione

: 401792-02-7
2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone

Guidance literature:: With hydrazine hydrate; In ethanol; for 24h; Reflux;
DOI:10.1016/j.bioorg.2018.05.013

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 401792-02-7
2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 80 percent / SOCl₂

2.1: 74 percent / Zn; aq. HCl / 3 h / 70 °C

3.1: aq. NaOH / 0.08 h / 20 °C

3.2: 92 percent / H₂O / 12 h

4.1: 80 percent / aq. NaOH / methanol / Heating

5.1: 3,4-dihydro-2H-pyran; p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 3 h / Heating

5.2: H₂O / 70 °C

5.3: 79 percent / aq. HCl / 4 h / pH 1 / Heating

6.1: 80 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

7.1: 88 percent / hydrazine monohydrate / ethanol / Heating

With 3,4-dihydro-2H-pyran; hydrogenchloride; sodium hydroxide; thionyl chloride; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; zinc; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm049751s

Reference yield:

: 7559-81-1,54839-86-0
chlorokojic acid

: 401792-02-7
2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 74 percent / Zn; aq. HCl / 3 h / 70 °C

2.1: aq. NaOH / 0.08 h / 20 °C

2.2: 92 percent / H₂O / 12 h

3.1: 80 percent / aq. NaOH / methanol / Heating

4.1: 3,4-dihydro-2H-pyran; p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 3 h / Heating

4.2: H₂O / 70 °C

4.3: 79 percent / aq. HCl / 4 h / pH 1 / Heating

5.1: 80 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

6.1: 88 percent / hydrazine monohydrate / ethanol / Heating

With 3,4-dihydro-2H-pyran; hydrogenchloride; sodium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; zinc; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm049751s