Carbamic acid, [(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[(4,4-dimethyl-2-oxo- 3-oxazolidinyl)methyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[(4,4-dimethyl-2-oxo- 3-oxazolidinyl)methyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester
CAS No.:401843-91-2
Molecular Formula:C31H46ClN3O5
Molecular Weight:576.176
Hs Code.:

Carbamic acid,
[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[(4,4-dimethyl-2-oxo-
3-oxazolidinyl)methyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[(4,4-dimethyl-2-oxo- 3-oxazolidinyl)methyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[(4,4-dimethyl-2-oxo- 3-oxazolidinyl)methyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

There total 6 articles about Carbamic acid, [(1R)-1-[(4-chlorophenyl)methyl]-2-[4-cyclohexyl-4-[(4,4-dimethyl-2-oxo- 3-oxazolidinyl)methyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-cyclohexyl-piperidin-4-ylmethyl)-4,4-dimethyl-oxazolidin-2-one; hydrochloride

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: 401843-91-2
{1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(4,4-dimethyl-2-oxo-oxazolidin-3-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmcl.2005.11.095

Reference yield:

: 363192-22-7
4-cyclohexyl-4-formyl-piperidine-1-carboxylic acid tert-butyl ester

: 401843-91-2
{1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(4,4-dimethyl-2-oxo-oxazolidin-3-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AcOH / toluene / Heating

2: H₂; AcOH / PtO₂

3: DIEA; DMAP / CH₂Cl₂

4: HCl / dioxane; CH₂Cl₂

5: EDC; HOBt; NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.11.095

Reference yield:

: 1-BOC-4-cyclohexyl-4-{N-[(2-hydroxy-1,1-dimethyl)ethyl]imino}piperidine

: 401843-91-2
{1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(4,4-dimethyl-2-oxo-oxazolidin-3-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂; AcOH / PtO₂

2: DIEA; DMAP / CH₂Cl₂

3: HCl / dioxane; CH₂Cl₂

4: EDC; HOBt; NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.11.095