Benzene, 1-[(1Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-bis(methoxy methoxy)-

Base Information

Chemical Name:Benzene, 1-[(1Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-bis(methoxy methoxy)-
CAS No.:402490-67-9
Molecular Formula:C20H23FO6
Molecular Weight:378.397
Hs Code.:

Synonyms:

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Chemical Property of Benzene, 1-[(1Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-bis(methoxy methoxy)-

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Technology Process of Benzene, 1-[(1Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-bis(methoxy methoxy)-

There total 3 articles about Benzene, 1-[(1Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-bis(methoxy methoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 162662-27-3
4-(methoxymethoxy)phenylboronic acid

: 402490-61-3
3,5-di-[(methoxymethyl)oxy]-β-bromo-β-fluorostyrene

: 402490-67-9
1-[(Z)-2-Fluoro-2-(4-methoxymethoxy-phenyl)-vinyl]-3,5-bis-methoxymethoxy-benzene

Guidance literature:: With tetrabutyl ammonium fluoride; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 5h; Heating;
DOI:10.1016/S0040-4039(01)01800-7

Reference yield:

: 76280-61-0
3,5-di-[(methoxymethyl)oxy]benzaldehyde

: 402490-67-9
1-[(Z)-2-Fluoro-2-(4-methoxymethoxy-phenyl)-vinyl]-3,5-bis-methoxymethoxy-benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / PPh₃; Zn(Cu) / tetrahydrofuran / 4 h / Heating

2: 71 percent / PPh₃; tetrabutylammonium fluoride trihydrate / PdCl₂(PPh₃)2 / tetrahydrofuran / 5 h / Heating

With zinc copper; tetrabutyl ammonium fluoride; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 2: Suzuki coupling;
DOI:10.1016/S0040-4039(01)01800-7

Reference yield:

: 26153-38-8
3,5-dihydroxybenzaldehyde

: 402490-67-9
1-[(Z)-2-Fluoro-2-(4-methoxymethoxy-phenyl)-vinyl]-3,5-bis-methoxymethoxy-benzene

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: triphenylphosphine / tetrahydrofuran / Reflux

3: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.biochem.7b00251