4-amino-1-(2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone

Base Information

Chemical Name:4-amino-1-(2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone
CAS No.:111795-59-6
Molecular Formula:C10H14 N6 O3
Molecular Weight:266.26
Hs Code.:
Mol file:111795-59-6.mol

Synonyms:2(1H)-Pyrimidinone,4-amino-1-[2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-, (1a,2b,3b,4a)- (9CI); 2(1H)-Pyrimidinone,4-amino-1-[2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-, (1a,2b,3b,4a)-(?à)-

Suppliers and Price of 4-amino-1-(2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-amino-1-(2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：152.11000
Density:g/cm³
LogP:-0.78624

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-amino-1-(2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone

There total 7 articles about 4-amino-1-(2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59967-83-8
(+/-)-1-<(1β,2α,3α,4β)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

: 111795-59-6
(+/-)-4-amino-1-<(1α,2β,3β,4α)-2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / NaHCO₃ / dimethylformamide; various solvent(s) / 0.5 h / 150 °C

2: 45 percent / LiN₃ / hexamethylphosphoric acid triamide / 150 °C

3: Py / 24 h / Ambient temperature

4: 61 percent / p-ClC₆H₄OPOCl₂, Py / 72 h / Ambient temperature

5: 1.) NH₂OH, 2.) NH₃ / 1.) dioxane, room temperature, 4 h, 2.) MeOH

With pyridine; lithium azide; ammonia; hydroxylamine; sodium hydrogencarbonate; 4-chlorophenylphosphorodichloridate; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00397a038

Reference yield:

: 62138-01-6,305384-32-1,780705-82-0
(+/-)-(1α,2α,3β,5β)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol

: 111795-59-6
(+/-)-4-amino-1-<(1α,2β,3β,4α)-2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 7 steps

1: benzene; dimethylformamide

2: 2N H₂SO₄

3: 67 percent / NaHCO₃ / dimethylformamide; various solvent(s) / 0.5 h / 150 °C

4: 45 percent / LiN₃ / hexamethylphosphoric acid triamide / 150 °C

5: Py / 24 h / Ambient temperature

6: 61 percent / p-ClC₆H₄OPOCl₂, Py / 72 h / Ambient temperature

7: 1.) NH₂OH, 2.) NH₃ / 1.) dioxane, room temperature, 4 h, 2.) MeOH

With pyridine; lithium azide; sulfuric acid; ammonia; hydroxylamine; sodium hydrogencarbonate; 4-chlorophenylphosphorodichloridate; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00397a038

Reference yield:

: 69975-22-0
(5aS,7S,8S,8aS)-8-Hydroxy-7-hydroxymethyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]oxazolo[3,2-a]pyrimidin-2-one

: 111795-59-6
(+/-)-4-amino-1-<(1α,2β,3β,4α)-2-azido-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / LiN₃ / hexamethylphosphoric acid triamide / 150 °C

2: Py / 24 h / Ambient temperature

3: 61 percent / p-ClC₆H₄OPOCl₂, Py / 72 h / Ambient temperature

4: 1.) NH₂OH, 2.) NH₃ / 1.) dioxane, room temperature, 4 h, 2.) MeOH

With pyridine; lithium azide; ammonia; hydroxylamine; 4-chlorophenylphosphorodichloridate; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00397a038