59967-83-8

Usage

Uses

Used in Pharmaceutical Industry:
1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione is used as a potential pharmaceutical agent for its unique molecular structure and functional groups, which may contribute to specific biological activities beneficial in the development of new drugs.
Used in Biochemical Research:
In the field of biochemistry, 1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione serves as a subject of study for understanding its interactions with biological systems, potentially leading to insights into new biochemical pathways or mechanisms of action.
Note: The specific applications and reasons for use provided here are hypothetical and based on the general potential of the compound's structure and functional groups. Actual applications would require empirical validation and research to confirm their feasibility and efficacy.

Upstream product

• 62102-29-8 (+/-)-N-<<(1α,2β,3β,4α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>carbamyl>-3-ethoxy-2-propenamide 
• 62138-01-6 (+/-)-(1α,2α,3β,5β)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol 

Downstream Products

• 59967-82-7 1-((3aS,4R,6R,6aR)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-1H-pyrimidine-2,4-dione 
• 62805-47-4 (+/-)-4-chloro-1-<(1α,2β,3β,4α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-2-(1H)pyrimidinone tribenzoate 
• 69975-12-8 (+/-)-1-<(1α,2β,3β,4α)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl>-4-(dimethylamino)-2-(1H)pyrimidinone 
• 62805-43-0 (+/-)-carbodine 
• 95313-01-2 (+/-)-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione diacetate 
• 91739-45-6 (+/-)-(E)-3-<1,2,3,4-tetrahydro-1-<<1α,3β,4α>-3-hydroxy-4-(hydroxymethyl)cyclopent-1-yl>-2,4-dioxo-5-pyrimidinyl>-2-propenoic acid 
• 83967-03-7 C-IDU 
• 95313-02-3 Acetic acid (1S,2R,4R)-2-acetoxymethyl-4-[5-((E)-2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-cyclopentyl ester 
• 95313-03-4 Acetic acid (1S,2R,4R)-2-acetoxymethyl-4-[4-amino-5-((E)-2-bromo-vinyl)-2-oxo-2H-pyrimidin-1-yl]-cyclopentyl ester 
• 95344-18-6 (+/-)-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-<(E)-2-carbomethoxyvinyl>-2,4(1H,3H)-pyrimidinedione 
• 91661-25-5 (+/-)-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-<(E)-2-iodovinyl>-2,4(1H,3H)-pyrimidinedione 
• 95313-04-5 (+/-)-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-4-amino-5-<(E)-2-bromovinyl>-2(1H)-pyrimidinone 
• 62102-28-7 (+/-)-1-<(1β,3α,4β)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione 
• 91661-22-2 (+/-)-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-<(E)-2-bromovinyl>-2,4(1H,3H)-pyrimidinedione 

Relevant academic research and scientific papers

Synthesis and Antiviral Evaluation of Carbocyclic Analogues of 2'-Azido- and 2'-Amino-2'-deoxycytidine

Carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine, compounds 8 and 9, were synthesized by an eight-step synthesis from (+/-)-(1α,2α,3β,5β)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol (1), which was prepared from cyclopentadiene via an eight-step route.These compounds were tested in vitro against herpes simplex virus type 1 (HSV-1).The 2'-amino analogue was found to show moderate antiviral activity, with an ED50 of 50 μM.However, the 2'-azido analogue was not active at a concentration up to 400 μM.

Synthesis of cyclopentane analogs of (2'- and 3'-deoxy-erythro-pentofuranosyl and ribofuranosyl)-2-thiouracil nucleosides

Three new carbocyclic analogus of nucleosides having the 2-thiouracil base have been synthesized.The cyclopentyl groups in these nucleosides are (+/-)- (see 31), (+/-)- (see 32) and (+/-)- (see 33).The nucleosides were prepared by coupling the appropriate hydroxy derivatives of cis-3-aminocyclopentanemethanol with 3-ethoxypropenoyl isothiocyanate (21) followed by cyclization in 15 N aqueous ammonia to give the 2-thiouracil nucleosides.In addition a modified and shortenedsynthetic route is described for the synthesys of (+/-)-(1β,2α,3α,4β)-4-amino-2,3-dihydroxy-cyclopentanemethanol (19).The (1)H nmr spectra at 200 MHz of all of the synthetic intermediates, the 2-thiouracil nucleosides, and of the corresponding carbocyclic analogs of uracil nucleosides are discussed.It is shown that each nucleoside has a characteristically unique (1)H nmr spectrum and that in general the protons in the sulfur-containing compounds resonate at lower filds than those in the corresponding oxygen-containing compounds.The magnitude of this downfield shift is inversely related to the number of bonds separating a particular proton from the sulfur atom.