Technology Process of 3-Oxazolidinecarboxylic acid, 5-acetyl-2-oxo-4-phenyl-,
1,1-dimethylethyl ester, (4R,5S)-
There total 3 articles about 3-Oxazolidinecarboxylic acid, 5-acetyl-2-oxo-4-phenyl-,
1,1-dimethylethyl ester, (4R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4R,5S)-5-acetyl-3-(4-methoxyphenyl)-4-phenyloxazolidin-2-one;
With
ammonium cerium(IV) nitrate;
In
water; acetonitrile;
at 0 ℃;
for 0.0833333h;
di-tert-butyl dicarbonate;
With
dmap; triethylamine;
In
dichloromethane;
at 20 ℃;
Further stages.;
DOI:10.1021/ja0174231
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (S)-proline / dimethylsulfoxide / 20 °C
2.1: 76 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
3.1: CAN / acetonitrile; H2O / 0.08 h / 0 °C
3.2: 80 percent / triethylamine; DMAP / CH2Cl2 / 20 °C
With
ammonium cerium(IV) nitrate; triethylamine; L-proline;
In
dichloromethane; water; dimethyl sulfoxide; acetonitrile;
1.1: Mannich reaction;
DOI:10.1021/ja0174231
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 76 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
2.1: CAN / acetonitrile; H2O / 0.08 h / 0 °C
2.2: 80 percent / triethylamine; DMAP / CH2Cl2 / 20 °C
With
ammonium cerium(IV) nitrate; triethylamine;
In
dichloromethane; water; acetonitrile;
DOI:10.1021/ja0174231
