Chemical Property of Canaline
Chemical Property:
- Vapor Pressure:9.22E-07mmHg at 25°C
- Refractive Index:1.51
- Boiling Point:378.1oC at 760mmHg
- PKA:pK1: 2.40;pK2: 3.70;pK3: 9.20 (25°C)
- Flash Point:182.5oC
- PSA：98.57000
- Density:1.298g/cm3
- LogP:0.07930
- Storage Temp.:2-8°C
- Solubility.:≤1mg/ml in DMSO
- XLogP3:-4.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:134.06914219
- Heavy Atom Count:9
- Complexity:95.8
- Purity/Quality:
-
97% *data from raw suppliers
(2S)-2-Amino-4-(aminooxy)butanoic acid 95% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C(CON)C(C(=O)O)N
- Isomeric SMILES:C(CON)[C@@H](C(=O)O)N
-
Description
L-Canaline is an aminooxy analog of ornithine that irreversibly inhibits aminotransferases (transaminases), including ornithine aminotransferase (Ki = 2 μM). It forms oximes with α-keto acids and aldehydes, most notably with pyridoxal phosphate, an essential cofactor of aminotransferases. L-Canaline is naturally found in plants, including legumes, and is involved in the metabolism of L-canavanine, an aminooxy analog of arginine. It is cytotoxic to a range of organisms, including bacteria, insects, and parasites.
