L-Valinamide, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-N-[(1S)-1-[( phenylmethoxy)methyl]-2-[4-(phenylmethoxy)phenyl]ethyl]-

Base Information

Chemical Name:L-Valinamide, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-N-[(1S)-1-[( phenylmethoxy)methyl]-2-[4-(phenylmethoxy)phenyl]ethyl]-
CAS No.:402832-93-3
Molecular Formula:C₄₉H₅₇N₃O₇
Molecular Weight:800.007
Hs Code.:

L-Valinamide,
N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-N-[(1S)-1-[(
phenylmethoxy)methyl]-2-[4-(phenylmethoxy)phenyl]ethyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Valinamide, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-N-[(1S)-1-[( phenylmethoxy)methyl]-2-[4-(phenylmethoxy)phenyl]ethyl]-

Chemical Property:

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Technology Process of L-Valinamide, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-N-[(1S)-1-[( phenylmethoxy)methyl]-2-[4-(phenylmethoxy)phenyl]ethyl]-

There total 7 articles about L-Valinamide, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosyl-N-[(1S)-1-[( phenylmethoxy)methyl]-2-[4-(phenylmethoxy)phenyl]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: (S)-2-Amino-N-[(S)-1-benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethyl]-3-methyl-butyramide

: 402832-93-3
[(S)-1-{(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.7164/antibiotics.54.1004

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 402832-93-3
[(S)-1-{(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.95 g / Et₃N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

3: 2.6 g / Et₃N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.7164/antibiotics.54.1004

Reference yield:

: 87745-27-5,40829-04-7
(S)-tyrosinol hydrochloride

: 402832-93-3
[(S)-1-{(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / NaOH / dioxane / 3 h / 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 0 °C

2.2: 74 percent / dimethylformamide / 5 h / 20 °C

3.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

4.1: 1.95 g / Et₃N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

5.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

6.1: 2.6 g / Et₃N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

With sodium hydroxide; sodium hydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.54.1004