Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester

Base Information

• Chemical Name: Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester
• CAS No.: 83345-46-4
• Molecular Formula: C14H21 N O4
• Molecular Weight: 267.325
• Mol file: 83345-46-4.mol

Synonyms:Carbamicacid, [(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester (9CI); Carbamic acid, [2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-,1,1-dimethylethyl ester, (S)-;(S)-[1-(Hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester;[(1S)-1-Hydroxymethyl-2-(4-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester;tert-Butyl [(S)-2-hydroxy-1-(4-hydroxybenzyl)ethyl]carbamate

Chemical Property of Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester

There total 12 articles about Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) → N-(tert-butyloxycarbonyl)-L-tyrosinol (83345-46-4,282100-80-5)

Guidance literature:

With sodium tetrahydroborate; calcium chloride;

DOI:10.1039/p19960001385

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-[(2S)-2-amino-3-hydroxypropyl]phenol (5034-68-4) → N-(tert-butyloxycarbonyl)-L-tyrosinol (83345-46-4,282100-80-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2008.07.125

Reference yield: 86.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-tyrosinol hydrochloride (87745-27-5,40829-04-7) → N-(tert-butyloxycarbonyl)-L-tyrosinol (83345-46-4,282100-80-5)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 16h;

DOI:10.1021/jo000242h

upstream raw materials:

Boc-Tyr-OH

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester

Downstream raw materials:

(S)-2-(tert-butoxycarbonylamino)-3-[4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecoxy) phenyl]-1-propanol

(-)-4-[4-{2-hydroxy-1-(4-hydroxybenzyl)ethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

N-t-butoxycarbonyl-di-O-acetyl-L-tyrosinol

[1-benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Refernces

• 1、 Cohen, Orit,Abu-Reziq, Raed,Gelman, Dmitri. "Chiral enantiopure organosilane precursors for the synthesis of periodic mesoporous organosilicas". . p. 1675 - 1685. Retrieved 2017/11/17.
• 2、 -. "ORALLY ADMINISTRABLE VIRIDIOFUNGIN DERIVATIVE HAVING ANTI-HCV ACTIVITY". Paragraph 1801; 1802; 1803. . Retrieved 2015/07/02.