3-Oxazolidinecarboxylic acid, 4-[(1R)-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-methyl propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[(1R)-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-methyl propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-
CAS No.:402925-41-1
Molecular Formula:C24H38N2O5
Molecular Weight:434.576
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[(1R)-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-methyl
propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Synonyms:

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[(1R)-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-methyl propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Chemical Property:

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Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 4-[(1R)-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-methyl propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

There total 4 articles about 3-Oxazolidinecarboxylic acid, 4-[(1R)-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-methyl propyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 402925-40-0
(4S,1'R)-2,2-dimethyl-4-(1'-methyl-3'-oxopropyl)oxazolidine-3-carboxylic acid tert-butyl ester

: 402925-41-1
(4S,1'R,1''S)-4-[3'-(1''-methoxycarbonyl-2''-phenyl-ethylamino)-1'-methylpropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1016/S0040-4039(01)01847-0

Reference yield:

: 131713-28-5
(1'R,4S)-4-(2'-ethoxycarbonyl-1'-methyl-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 402925-41-1
(4S,1'R,1''S)-4-[3'-(1''-methoxycarbonyl-2''-phenyl-ethylamino)-1'-methylpropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 20 °C

2: 96 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3: 90 percent / sodium triacetoxyborohydride / tetrahydrofuran / 15 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1021/jo050736k

Reference yield:

: 515173-87-2
(1'R,4S)-4-(3'-hydroxy-1'-methyl-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 402925-41-1
(4S,1'R,1''S)-4-[3'-(1''-methoxycarbonyl-2''-phenyl-ethylamino)-1'-methylpropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2: 90 percent / sodium triacetoxyborohydride / tetrahydrofuran / 15 h / 20 °C

With oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1: Swern oxidation;
DOI:10.1021/jo050736k