3-METHYLTHIO-1,2,4-TRIAZINO[5,6-B]INDOLE

Base Information

• Chemical Name: 3-METHYLTHIO-1,2,4-TRIAZINO[5,6-B]INDOLE
• CAS No.: 4030-04-0
• Molecular Formula: C10H8N4S
• Molecular Weight: 216.26200
• Mol file: 4030-04-0.mol

Synonyms:3-Methylthio-5-(1,2,4)triazino(5,6)indol;2-Methylmercapto-1,3,4-triazacarbazol;3-Methylthio-1,2,4-triazino(5,6-b)indole;3-methylsulfanyl-5H-[1,2,4]triazino[5,6-b]indole;

Chemical Property of 3-METHYLTHIO-1,2,4-TRIAZINO[5,6-B]INDOLE

Chemical Property:

• PSA: 79.76000
• LogP: 2.22800

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-METHYLTHIO-1,2,4-TRIAZINO[5,6-B]INDOLE

There total 5 articles about 3-METHYLTHIO-1,2,4-TRIAZINO[5,6-B]INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-mercapto-5H-1,2,4-triazino[5,6-b]indole (28668-95-3) + methyl iodide (74-88-4) → 3-Methylthio-1,2,4-triazino<5,6-b>indole (4030-04-0)

Guidance literature:

With potassium carbonate; at 20 ℃; for 16h; Reagent/catalyst;

DOI:10.1016/j.bmc.2014.11.002

Reference yield: 69.0%

methyl bromide (74-83-9) + 3-mercapto-5H-1,2,4-triazino[5,6-b]indole (28668-95-3) → 3-Methylthio-1,2,4-triazino<5,6-b>indole (4030-04-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1021/acschemneuro.9b00226

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-Methylthio-1,2,4-triazino<5,6-b>indole (4030-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid

2: potassium hydroxide

3: sodium hydroxide

With acetic acid; potassium hydroxide; sodium hydroxide;

DOI:10.2298/JSC120914013G

upstream raw materials:

3-mercapto-5H-1,2,4-triazino[5,6-b]indole

methyl iodide

indole-2,3-dione 3-thiosemicarbazone

indole-2,3-dione