Benzenepropanoic acid, b-[[3-[2,3-dihydro-6-[[[(phenylmethyl)amino]carbonyl]amino]-1H-indol-1- yl]-1,3-dioxopropyl]amino]-, methyl ester

Base Information

Chemical Name:Benzenepropanoic acid, b-[[3-[2,3-dihydro-6-[[[(phenylmethyl)amino]carbonyl]amino]-1H-indol-1- yl]-1,3-dioxopropyl]amino]-, methyl ester
CAS No.:403600-03-3
Molecular Formula:C29H30N4O5
Molecular Weight:514.581
Hs Code.:

Synonyms:

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Chemical Property of Benzenepropanoic acid, b-[[3-[2,3-dihydro-6-[[[(phenylmethyl)amino]carbonyl]amino]-1H-indol-1- yl]-1,3-dioxopropyl]amino]-, methyl ester

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Technology Process of Benzenepropanoic acid, b-[[3-[2,3-dihydro-6-[[[(phenylmethyl)amino]carbonyl]amino]-1H-indol-1- yl]-1,3-dioxopropyl]amino]-, methyl ester

There total 5 articles about Benzenepropanoic acid, b-[[3-[2,3-dihydro-6-[[[(phenylmethyl)amino]carbonyl]amino]-1H-indol-1- yl]-1,3-dioxopropyl]amino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 14898-52-3
methyl 3-amino-3-phenylpropanoate

: 229636-39-9
3-[6-(3-benzylureido)indolin-1-yl]-3-oxopropanoic acid

: 403600-03-3
(R,S)-methyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxopropanoylamino}-3-phenylpropanoate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1248/cpb.49.1420

Reference yield:

: 19727-83-4
6-nitroindoline

: 403600-03-3
(R,S)-methyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxopropanoylamino}-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / Et₃N / CHCl₃ / 14 h / 20 °C

2: 1.51 g / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

3: 92 percent / acetonitrile / 12 h / 20 °C

4: 1.91 g / 1 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C

5: 100 percent / HOBt; EDC; Et₃N / dimethylformamide / 17 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1420

Reference yield:

: 229636-36-6
ethyl 3-(6-nitroindolin-1-yl)-3-oxopropanoate

: 403600-03-3
(R,S)-methyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxopropanoylamino}-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.51 g / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

2: 92 percent / acetonitrile / 12 h / 20 °C

3: 1.91 g / 1 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C

4: 100 percent / HOBt; EDC; Et₃N / dimethylformamide / 17 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1420