14898-52-3

Basic information

• Product Name: methyl 3-amino-3-phenylpropanoate
• Synonyms: methyl 3-amino-3-phenylpropanoate;Benzenepropanoic acid, b-aMino-, Methyl ester;Methyl3-aMino-3-phehylpropanoate;Benzenepropanoic acid, β-amino-, methyl ester
• CAS NO: 14898-52-3
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• Mol File: 14898-52-3.mol
• Article Data: 38

Chemical Properties

• Melting Point: 148-149 °C
• Boiling Point: 283°C at 760 mmHg
• Flash Point: 141.7°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.00324mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.68±0.10(Predicted)
• CAS DataBase Reference: methyl 3-amino-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-amino-3-phenylpropanoate(14898-52-3)
• EPA Substance Registry System: methyl 3-amino-3-phenylpropanoate(14898-52-3)

Safety Data

• Hazardous Substances Data: 14898-52-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 50, p. 8099, 1994 DOI: 10.1016/S0040-4020(01)85292-3

InChI:InChI=1/C10H13NO2/c1-13-10(12)7-9(11)8-5-3-2-4-6-8/h2-6,9H,7,11H2,1H3

Upstream product

• 22838-46-6 methyl 3-amino-3-phenylpropionate hydrochloride 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 67-56-1 methanol 
• 141-82-2 malonic acid 
• 100-52-7 benzaldehyde 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 157371-84-1 1-Phenyl-2-(2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-3-yl)-ethanone oxime 
• 157371-83-0 3-phenacyl-2,4,10-trioxaadamantane 
• 157371-82-9 (2,4,10-trioxaadamantylmethyl)phenylcarbinol 
• 157371-85-2 1-Phenyl-2-(2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-3-yl)-ethylamine 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 257861-50-0 3-tert-butoxycarbonylamino-3-phenylpropionic acid methyl ester 
• 223660-69-3 methyl 3-(2-methoxyphenyl)amino-3-phenylpropionate 
• 53030-50-5 3-amino-3-phenyl-DL-propionyl chloride 

Downstream Products

• 1243990-24-0 C₂₈H₃₅N₃O₆ 
• 193633-65-7 (R,S)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid 
• 1605291-17-5 N-4-nitrophenyl-β-phenylalanine methyl ester 

Relevant articles and documents

β-Amino esters via the Reformatsky reaction: Restraining effects of the ortho-methoxyphenyl substituent

β-Amino esters are, in most cases, the only products of the Reformatsky reaction in CH2Cl2 between (methoxycarbonyl)methyl zinc bromide (prepared in-situ) and imines prepared from either an aryl or alkyl aldehyde and o- anisdine (Sch

Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts

A transition metal-free approach for the N-arylation of amino acid derivatives has been developed. Key to this method is the use of unsymmetric diaryliodonium salts with anisyl ligands, which proved important to obtain high chemoselectivity and yields. The scope includes the transfer of both electron deficient, electron rich and sterically hindered aryl groups with a variety of different functional groups. Furthermore, a cyclic diaryliodonium salt was successfully employed in the arylation. The N-arylated products were obtained with retained enantiomeric excess.

Intermolecular Radical C(sp3)?H Amination under Iodine Catalysis

The direct amination of aliphatic C?H bonds has remained one of the most tantalizing transformations in organic chemistry. Herein, we report on a unique catalyst system, which enables the elusive intermolecular C(sp3)?H amination. This practical synthetic strategy provides access to aminated building blocks and fosters innovative multiple C?H amination within a new approach to aminated heterocycles. The synthetic utility is demonstrated by the synthesis of four relevant pharmaceuticals.