16-formylestradiol

Base Information

• Chemical Name: 16-formylestradiol
• CAS No.: 150585-08-3
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.398
• Mol file: 150585-08-3.mol

Synonyms:16-formylestradiol

Chemical Property of 16-formylestradiol

Chemical Property:

• Vapor Pressure: 1.9E-10mmHg at 25°C
• Boiling Point: 490.8°Cat760mmHg
• Flash Point: 264.7°C
• PSA: 57.53000
• Density: 1.255g/cm³
• LogP: 3.03420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16-formylestradiol

There total 6 articles about 16-formylestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

16-methoxymethylene-3,17β-dihydroxyestra-1,3,5(10)-triene (150585-10-7) → 16-formyl-3,17β-dihydroxyestra-1,3,5(10)-triene (150585-08-3)

Guidance literature:

With hydrogenchloride; In acetone; for 0.333333h; Ambient temperature;

DOI:10.1016/0039-128X(93)90025-I

Reference yield:

Estrone (53-16-7) → 16-formyl-3,17β-dihydroxyestra-1,3,5(10)-triene (150585-08-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) sodium hydride / 1.) benzene, 1 h, 2.) benzene, RT

2: 86 percent / CeCl₃ / methanol / Ambient temperature

3: CeCl₃, sodium borohydride / methanol / 0.75 h

4: 70 percent / 2 N HCl / acetone / 0.33 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; sodium hydride; In methanol; acetone;

DOI:10.1016/0039-128X(93)90025-I

Reference yield:

3-hydroxy-16-hydroxymethylideneestra-1,3,5(10)-trien-17-one (3460-92-2) → 16-formyl-3,17β-dihydroxyestra-1,3,5(10)-triene (150585-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / CeCl₃ / methanol / Ambient temperature

2: CeCl₃, sodium borohydride / methanol / 0.75 h

3: 70 percent / 2 N HCl / acetone / 0.33 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; In methanol; acetone;

DOI:10.1016/0039-128X(93)90025-I

upstream raw materials:

16-methoxymethylene-3,17β-dihydroxyestra-1,3,5(10)-triene

16-dimethoxymethyl-3,17β-dihydroxyestra-1,3,5(10)-triene

Estrone

3-hydroxy-16-hydroxymethylideneestra-1,3,5⁽¹⁰⁾-trien-17-one

Refernces