Benzene, [[[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentyl]methoxy]methyl] -

Base Information

Chemical Name:Benzene, [[[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentyl]methoxy]methyl] -
CAS No.:404338-79-0
Molecular Formula:C17H22O3
Molecular Weight:274.36
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzene, [[[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentyl]methoxy]methyl] -

Chemical Property:

Purity/Quality:

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Technology Process of Benzene, [[[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentyl]methoxy]methyl] -

There total 12 articles about Benzene, [[[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentyl]methoxy]methyl] - which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 404338-96-1
[(1R,2R,4R)-2-(1,2-Dibromo-ethyl)-4-methoxymethoxy-cyclopentylmethoxymethyl]-benzene

: 404338-79-0
[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentylmethoxymethyl]benzene

Guidance literature:: With sodium amide; In tetrahydrofuran; ammonia; for 0.5h; Heating;
DOI:10.1021/jo010744a

Reference yield:

: 100-39-0
benzyl bromide

: 404338-79-0
[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentylmethoxymethyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / NaH; tetrabutylammonium iodide / dimethylformamide / 20 °C

2: pyridinium tribromide; pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3: 82 percent / NaNH₂ / tetrahydrofuran; liquid ammonia / 0.5 h / Heating

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium amide; pyridinium hydrobromide perbromide; In tetrahydrofuran; dichloromethane; ammonia; N,N-dimethyl-formamide;
DOI:10.1021/jo010744a

Reference yield:

: 89408-85-5
(S)-6-(hydroxymethyl)-5,6-dihydro-2H-pyran-2-one

: 404338-79-0
[(1R,2R,4S)-2-ethynyl-4-(methoxymethoxy)cyclopentylmethoxymethyl]benzene

Guidance literature:: Multi-step reaction with 11 steps

1.1: 97 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / 20 °C

2.1: CuI / tetrahydrofuran / 0.5 h / -35 °C

2.2: 83 percent / tetrahydrofuran / 1 h / -35 - -25 °C

3.1: 88 percent / Ti(O-i-Pr)4 / 24 h / Heating

4.1: 91 percent / diisopropylethylamine / CH₂Cl₂ / 18 h / 20 °C

5.1: 96 percent / TBAF / tetrahydrofuran / 20 °C

6.1: 96 percent / Ph₃P; imidazole; I₂ / tetrahydrofuran / 3 h / 20 °C

7.1: 92 percent / LHMDS / tetrahydrofuran / 0.5 h / 0 °C

8.1: 100 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

9.1: 96 percent / NaH; tetrabutylammonium iodide / dimethylformamide / 20 °C

10.1: pyridinium tribromide; pyridine / CH₂Cl₂ / 0.5 h / 0 °C

11.1: 82 percent / NaNH₂ / tetrahydrofuran; liquid ammonia / 0.5 h / Heating

With pyridine; 1H-imidazole; titanium(IV) isopropylate; dmap; copper(l) iodide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium amide; pyridinium hydrobromide perbromide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ammonia; N,N-dimethyl-formamide;
DOI:10.1021/jo010744a