2,5-Dioxooxazolidine-4-propionic acid

Base Information

• Chemical Name: 2,5-Dioxooxazolidine-4-propionic acid
• CAS No.: 3981-39-3
• Molecular Formula: C₆H₇NO₅
• Molecular Weight: 173.125
• European Community (EC) Number: 223-617-9
• DSSTox Substance ID: DTXSID20960374
• Nikkaji Number: J217.811G
• Mol file: 3981-39-3.mol

Synonyms:3981-39-3;2,5-Dioxooxazolidine-4-propionic acid;3-(2,5-dioxo-1,3-oxazolidin-4-yl)propanoic acid;EINECS 223-617-9;SCHEMBL5672364;DTXSID20960374;2,5-Dioxo-4-oxazolidinepropionic acid;FT-0750656;3-(2-Hydroxy-5-oxo-4,5-dihydro-1,3-oxazol-4-yl)propanoic acid

Chemical Property of 2,5-Dioxooxazolidine-4-propionic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.473g/cm³
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 173.03242232
• Heavy Atom Count: 12
• Complexity: 236

Purity/Quality:

98%Min ^*data from raw suppliers

3-(2,5-DIOXO-OXAZOLIDIN-4-YL)PROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)O)C1C(=O)OC(=O)N1

Technology Process of 2,5-Dioxooxazolidine-4-propionic acid

There total 6 articles about 2,5-Dioxooxazolidine-4-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

L-N-benzyloxycarbonylglutamic acid → 3-(2,5-dioxo-oxazolidin-4-yl)-propionic acid (3981-39-3,33043-68-4)

Guidance literature:

With benzoic acid; In butanone; at 80 ℃; for 29h; Inert atmosphere; Molecular sieve;

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → 3-(2,5-dioxo-oxazolidin-4-yl)-propionic acid (3981-39-3,33043-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra(n-butyl)ammonium hydroxide / butanone; methanol / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

1.2: 20 h / Inert atmosphere

2.1: benzoic acid / butanone / 29 h / 80 °C / Inert atmosphere; Molecular sieve

With tetra(n-butyl)ammonium hydroxide; benzoic acid; In methanol; butanone;

Reference yield:

1-ethyl-3-methylimidazolium 1-aminopropane-1,3-dicarboxylic acid salt → 3-(2,5-dioxo-oxazolidin-4-yl)-propionic acid (3981-39-3,33043-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2: benzoic acid / butanone / 29 h / 80 °C / Inert atmosphere; Molecular sieve

With benzoic acid; In acetonitrile; butanone;

upstream raw materials:

phosgene

Glutamic acid

L-glutamic acid

bis(trichloromethyl) carbonate

Refernces

• 1、 -. "PREPARATION OF ORGANIC COMPOUNDS FOR ENHANCED REACTIVITY". Page/Page column 9. . Retrieved 2010/06/16.