1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 3-[(2-amino-1-cyano-2-thioxoethylidene)hydrazino]-4-[4-(dimethylamino )phenyl]-6-methyl-, ethyl ester

Base Information

Chemical Name:1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 3-[(2-amino-1-cyano-2-thioxoethylidene)hydrazino]-4-[4-(dimethylamino )phenyl]-6-methyl-, ethyl ester
CAS No.:404588-47-2
Molecular Formula:C21H22N8O2S
Molecular Weight:450.524
Hs Code.:

1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid,
3-[(2-amino-1-cyano-2-thioxoethylidene)hydrazino]-4-[4-(dimethylamino
)phenyl]-6-methyl-, ethyl ester

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Chemical Property of 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 3-[(2-amino-1-cyano-2-thioxoethylidene)hydrazino]-4-[4-(dimethylamino )phenyl]-6-methyl-, ethyl ester

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Technology Process of 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 3-[(2-amino-1-cyano-2-thioxoethylidene)hydrazino]-4-[4-(dimethylamino )phenyl]-6-methyl-, ethyl ester

There total 6 articles about 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 3-[(2-amino-1-cyano-2-thioxoethylidene)hydrazino]-4-[4-(dimethylamino )phenyl]-6-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 7357-70-2
Cyanothioacetamide

: 404588-41-6
C₁₈H₁₉ClN₆O₂

: 404588-47-2
3-[N'-(cyano-thiocarbamoyl-methylene)-hydrazino]-4-(4-dimethylamino-phenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: With sodium acetate; In ethanol; at 20 ℃; for 1h;
DOI:10.1080/10426500108040253

Reference yield:

: 68029-58-3,37401-21-1
2-cyano-3-(4-(dimethylamino)phenyl)prop-2-enethioamide

: 404588-47-2
3-[N'-(cyano-thiocarbamoyl-methylene)-hydrazino]-4-(4-dimethylamino-phenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / ethanol

2: 85 percent / NaOMe / methanol / 5 h / Heating

3: 65 percent / hydrazine hydrate / ethanol / 6 h / Heating

4: 62 percent / conc. HCl; sodium nitrite / 1 h / 0 °C

5: 73 percent / AcONa / ethanol / 1 h / 20 °C

With pyridine; hydrogenchloride; sodium methylate; sodium acetate; hydrazine hydrate; sodium nitrite; In methanol; ethanol;
DOI:10.1080/10426500108040253

Reference yield:

: 141-97-9
ethyl acetoacetate

: 404588-47-2
3-[N'-(cyano-thiocarbamoyl-methylene)-hydrazino]-4-(4-dimethylamino-phenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / ethanol

2: 85 percent / NaOMe / methanol / 5 h / Heating

3: 65 percent / hydrazine hydrate / ethanol / 6 h / Heating

4: 62 percent / conc. HCl; sodium nitrite / 1 h / 0 °C

5: 73 percent / AcONa / ethanol / 1 h / 20 °C

With pyridine; hydrogenchloride; sodium methylate; sodium acetate; hydrazine hydrate; sodium nitrite; In methanol; ethanol;
DOI:10.1080/10426500108040253