Guanidine, [4,5,6,7-tetrahydro-4-(hydroxymethyl)-2-benzothiazolyl]-

Base Information

• Chemical Name: Guanidine, [4,5,6,7-tetrahydro-4-(hydroxymethyl)-2-benzothiazolyl]-
• CAS No.: 405071-61-6
• Molecular Formula: C₉H₁₄N₄OS
• Molecular Weight: 226.302
• Mol file: 405071-61-6.mol

Synonyms:N-(4-Hydroxymethyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-guanidine;

Chemical Property of Guanidine, [4,5,6,7-tetrahydro-4-(hydroxymethyl)-2-benzothiazolyl]-

Chemical Property:

• Melting Point: 81 - 85 °C
• PSA: 123.26000
• LogP: 1.73370

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Guanidine, [4,5,6,7-tetrahydro-4-(hydroxymethyl)-2-benzothiazolyl]-

There total 1 articles about Guanidine, [4,5,6,7-tetrahydro-4-(hydroxymethyl)-2-benzothiazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethyl 2-{[amino(imino)methyl]amino}-4,5,6,7-tetrahdyro-1,3-benzothiazole-4-carboxylate hydrobromide → 4,5,6,7-tetrahydro-1,3-benzothiazol-4-ylmethanamine (77528-47-3) + (2-amino-4,5,5,6-tetrahydrobenzo[d]thiazol-4-yl)methanol (405071-50-3) + N-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-guanidine (405071-61-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h;

DOI:10.1016/S0040-4039(01)01939-6

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + N-(4-hydroxymethyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-guanidine (405071-61-6) → N-(4-tosyloxymethyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-guanidine (405071-87-6)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1016/S0040-4039(01)01939-6

Downstream raw materials:

N-(4-tosyloxymethyl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-guanidine