Benzenebutanoic acid, 2,4-difluoro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Benzenebutanoic acid, 2,4-difluoro-, 1,1-dimethylethyl ester
CAS No.:405196-44-3
Molecular Formula:C14H18F2O2
Molecular Weight:256.293
Hs Code.:

Synonyms:

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Chemical Property of Benzenebutanoic acid, 2,4-difluoro-, 1,1-dimethylethyl ester

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Technology Process of Benzenebutanoic acid, 2,4-difluoro-, 1,1-dimethylethyl ester

There total 4 articles about Benzenebutanoic acid, 2,4-difluoro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 4-(2,4-difluoro-phenyl)-4-(imidazole-1-carbothioyloxy)-butyric acid tert-butyl ester

: 405196-44-3
4-(2,4-difluorophenyl)butanoic acid 1,1-dimethylethyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1.5h; Heating;
DOI:10.1021/jo0160322

Reference yield:

: 49827-15-8
t-butyl iodoacetate

: 405196-44-3
4-(2,4-difluorophenyl)butanoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / lithium hexamethyldisilazide / tetrahydrofuran / 3 h / -78 - 20 °C

2: 100 percent / sodium borohydride / tetrahydrofuran; H₂O / 2.5 h / 20 °C

3: 92 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 20 °C

4: 96 percent / tributyltin hydride; AIBN / toluene / 1.5 h / Heating

With dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo0160322

Reference yield:

: 405196-43-2
4-(2,4-difluorophenyl)-4-hydroxybutanoic acid 1,1-dimethylethyl ester

: 405196-44-3
4-(2,4-difluorophenyl)butanoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 20 °C

2: 96 percent / tributyltin hydride; AIBN / toluene / 1.5 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In dichloromethane; toluene;
DOI:10.1021/jo0160322