4-Hmclc

Base Information

Chemical Name:4-Hmclc
CAS No.:3986-03-6
Molecular Formula:C₂₃H₂₇NO₇
Molecular Weight:429.47
Hs Code.:
Mol file:3986-03-6.mol

Synonyms:Colchicine,1-(hydroxymethyl)- (7CI); Colchicine, 4-(hydroxymethyl)- (8CI);Benzo[a]heptalene, acetamide deriv.; 4-(Hydroxymethyl)colchicine; NSC 99420

Suppliers and Price of 4-Hmclc

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-Hmclc

Chemical Property:

Vapor Pressure:1.74E-25mmHg at 25°C
Boiling Point:778.1°Cat760mmHg
Flash Point:424.4°C
PSA：103.32000
Density:1.29g/cm³
LogP:2.75480

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Hmclc

There total 4 articles about 4-Hmclc which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2730-82-7
4-Formylcolchicine

: 3986-03-6
1-Hydroxymethyl-colchicin

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c3md00287j

Reference yield: 60.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 64-86-8,54192-66-4
colchicine

: 3986-03-6
1-Hydroxymethyl-colchicin

Guidance literature:: With sulfuric acid; water; at 20 ℃; for 0.666667h;
DOI:10.1002/hlca.200490203

Reference yield:

: 64-86-8,54192-66-4
colchicine

: 3986-03-6
1-Hydroxymethyl-colchicin

Guidance literature:: Multi-step reaction with 2 steps

1: tin(IV) chloride / dichloromethane / 20 °C

2: sodium tetrahydroborate / methanol / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tin(IV) chloride; In methanol; dichloromethane;
DOI:10.1039/c3md00287j