Chemical Property of Lupiwighteone
Chemical Property:
- Vapor Pressure:3.25E-14mmHg at 25°C
- Melting Point:133-135℃
- Boiling Point:583.5°C at 760 mmHg
- Flash Point:211.8°C
- PSA:90.90000
- Density:1.351g/cm3
- LogP:4.08550
- XLogP3:4.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:338.11542367
- Heavy Atom Count:25
- Complexity:554
- Purity/Quality:
-
99% *data from raw suppliers
Lupiwighteone *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=CO2)C3=CC=C(C=C3)O)C
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Uses
Lupiwighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.