2-(diethylamino)-1-(quinolin-8-yl)ethanol

Base Information

• Chemical Name: 2-(diethylamino)-1-(quinolin-8-yl)ethanol
• CAS No.: 5422-55-9
• Molecular Formula: C₁₅H₂₀N₂O
• Molecular Weight: 244.337
• Mol file: 5422-55-9.mol

Synonyms:

Chemical Property of 2-(diethylamino)-1-(quinolin-8-yl)ethanol

Chemical Property:

• Vapor Pressure: 2.82E-07mmHg at 25°C
• Boiling Point: 404.7°Cat760mmHg
• Flash Point: 198.6°C
• Density: 1.104g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(diethylamino)-1-(quinolin-8-yl)ethanol

There total 5 articles about 2-(diethylamino)-1-(quinolin-8-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-carboxyquinoline (86-59-9) → 1-[8]quinolyl-2-diethylamino-ethanol (5422-55-9)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / Erwaermen des Reaktionsprodukts mit Aethanol

2: sodium ethylate; toluene / 110 °C / und Erwaermen des erhaltenen Reaktionsprodukts mit wss. Schwefelsaeure

3: hydrobromic acid; water; bromine

4: diethyl ether / Erwaermen des Reaktionsprodukts mit Aluminiumisopropylat in Isopropylalkohol

With thionyl chloride; diethyl ether; water; hydrogen bromide; bromine; sodium ethanolate; toluene;

DOI:10.1021/ja01213a046

Reference yield:

quinoline-8-carboxylic acid ethylester (25635-22-7) → 1-[8]quinolyl-2-diethylamino-ethanol (5422-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethylate; toluene / 110 °C / und Erwaermen des erhaltenen Reaktionsprodukts mit wss. Schwefelsaeure

2: hydrobromic acid; water; bromine

3: diethyl ether / Erwaermen des Reaktionsprodukts mit Aluminiumisopropylat in Isopropylalkohol

With diethyl ether; water; hydrogen bromide; bromine; sodium ethanolate; toluene;

DOI:10.1021/ja01213a046

Reference yield:

1-(quinolin-8-yl)ethan-1-one (56234-20-9) → 1-[8]quinolyl-2-diethylamino-ethanol (5422-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrobromic acid; water; bromine

2: diethyl ether / Erwaermen des Reaktionsprodukts mit Aluminiumisopropylat in Isopropylalkohol

With diethyl ether; water; hydrogen bromide; bromine;

DOI:10.1021/ja01213a046

upstream raw materials:

2-bromo-1-[8]quinolyl-ethanone; hydrobromide

diethylamine

8-carboxyquinoline

quinoline-8-carboxylic acid ethylester