8-Bromoacetylquinoline hydrobromide

Base Information

• Chemical Name: 8-Bromoacetylquinoline hydrobromide
• CAS No.: 859962-48-4
• Molecular Formula: BrH*C₁₁H₈BrNO
• Molecular Weight: 331.007
• Hs Code.: 2933499090
• Mol file: 859962-48-4.mol

Synonyms:Ketone,bromomethyl 8-quinolyl, -HBr (4CI)

Chemical Property of 8-Bromoacetylquinoline hydrobromide

Chemical Property:

• Vapor Pressure: 1.21E-06mmHg at 25°C
• Boiling Point: 392.2oC at 760 mmHg
• Flash Point: 191oC
• PSA: 29.96000
• LogP: 3.77050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

8-(Bromoacetyl)quinoline hydrobromide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Bromoacetylquinoline hydrobromide

There total 4 articles about 8-Bromoacetylquinoline hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(quinolin-8-yl)ethan-1-one (56234-20-9) → 2-bromo-1-[8]quinolyl-ethanone; hydrobromide (859962-48-4)

Guidance literature:

With water; hydrogen bromide; bromine;

DOI:10.1021/ja01213a046

Reference yield:

8-carboxyquinoline (86-59-9) → 2-bromo-1-[8]quinolyl-ethanone; hydrobromide (859962-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / Erwaermen des Reaktionsprodukts mit Aethanol

2: sodium ethylate; toluene / 110 °C / und Erwaermen des erhaltenen Reaktionsprodukts mit wss. Schwefelsaeure

3: hydrobromic acid; water; bromine

With thionyl chloride; water; hydrogen bromide; bromine; sodium ethanolate; toluene;

DOI:10.1021/ja01213a046

Reference yield:

quinoline-8-carboxylic acid ethylester (25635-22-7) → 2-bromo-1-[8]quinolyl-ethanone; hydrobromide (859962-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethylate; toluene / 110 °C / und Erwaermen des erhaltenen Reaktionsprodukts mit wss. Schwefelsaeure

2: hydrobromic acid; water; bromine

With water; hydrogen bromide; bromine; sodium ethanolate; toluene;

DOI:10.1021/ja01213a046

upstream raw materials:

1-(quinolin-8-yl)ethan-1-one

8-carboxyquinoline

quinoline-8-carboxylic acid ethylester

anthranilic acid

Downstream raw materials:

1-[8]quinolyl-2-diethylamino-ethanol