1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol -1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol -1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-
CAS No.:405940-74-1
Molecular Formula:C24H18F5N7O
Molecular Weight:515.445
Hs Code.:
Mol file:405940-74-1.mol

1H-Pyrazole-5-carboxamide,
1-(3-cyano-4-fluorophenyl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol
-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

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Chemical Property of 1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol -1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

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Technology Process of 1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol -1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

There total 7 articles about 1H-Pyrazole-5-carboxamide, 1-(3-cyano-4-fluorophenyl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol -1-yl]-2-fluorophenyl]-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 218301-68-9
1-(4-amino-3-fluoro)phenyl-2-(N,N-dimethylamino)methylimidazole

: 405940-74-1
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0497949

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 405940-74-1
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

2: 56.1 g / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm0497949

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 405940-74-1
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / SnCl₂*2H₂O / ethyl acetate / 1.5 h / Heating

2.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

2.2: stannous chloride; aq. HCl / 12 h / 0 °C

2.3: 7.0 g / acetic acid / 12 h / Heating

3.1: 64 percent / RuCl₃; aq. NaIO₄ / acetonitrile; CCl₄ / 12 h / 20 °C

4.1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

5.1: 56.1 g / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; dmap; ruthenium trichloride; sodium periodate; oxalyl dichloride; N,N-dimethyl-formamide; tin(ll) chloride; sodium nitrite; In tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm0497949