Silane, (1,1-dimethylethyl)[(1S)-1-[(S)-iodo[(2S,5R)-tetrahydro-5-[(1S)-1-methyl -2-(phenylmethoxy)ethyl]-2-furanyl]methyl]butoxy]dimethyl-

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Chemical Name:Silane, (1,1-dimethylethyl)[(1S)-1-[(S)-iodo[(2S,5R)-tetrahydro-5-[(1S)-1-methyl -2-(phenylmethoxy)ethyl]-2-furanyl]methyl]butoxy]dimethyl-
CAS No.:406674-46-2
Molecular Formula:C25H43IO3Si
Molecular Weight:546.605
Hs Code.:

Synonyms:

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Chemical Property of Silane, (1,1-dimethylethyl)[(1S)-1-[(S)-iodo[(2S,5R)-tetrahydro-5-[(1S)-1-methyl -2-(phenylmethoxy)ethyl]-2-furanyl]methyl]butoxy]dimethyl-

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Technology Process of Silane, (1,1-dimethylethyl)[(1S)-1-[(S)-iodo[(2S,5R)-tetrahydro-5-[(1S)-1-methyl -2-(phenylmethoxy)ethyl]-2-furanyl]methyl]butoxy]dimethyl-

There total 10 articles about Silane, (1,1-dimethylethyl)[(1S)-1-[(S)-iodo[(2S,5R)-tetrahydro-5-[(1S)-1-methyl -2-(phenylmethoxy)ethyl]-2-furanyl]methyl]butoxy]dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 406674-27-9
(2S,3R,8S)-1-benzyloxy-3-tert-butoxy-8-(tert-butyldimethylsilyl)oxy-2-methyl-6-undecene

: 406674-46-2
(2S,3R,6S,7R,8S)-1-benzyloxy-8-(tert-butyldimethylsilyl)oxy-3,6-epoxy-7-iodo-2-methylundecane

Guidance literature:: With iodine; sodium hydrogencarbonate; In acetonitrile; at 40 ℃; for 96h;
DOI:10.1271/bbb.65.2630

Reference yield:

: 81380-10-1
(2S,3S)-4-benzyloxy-1,2-epoxy-3-methylbutane

: 406674-46-2
(2S,3R,6S,7R,8S)-1-benzyloxy-8-(tert-butyldimethylsilyl)oxy-3,6-epoxy-7-iodo-2-methylundecane

Guidance literature:: Multi-step reaction with 10 steps

1.1: CuI / diethyl ether / 0.5 h / -30 °C

1.2: 98 percent / diethyl ether / -30 - -20 °C

2.1: 78 percent / Amberlyst H-15 / hexane / -78 - 20 °C

3.1: NMO; OsO₄ / tetrahydrofuran; H₂O / 0 - 20 °C

4.1: NaIO₄ / tetrahydrofuran; H₂O / 0.5 h / 20 °C

5.1: 0.43 g / LiAlH₄ / diethyl ether / 2 h / -78 °C

6.1: (n-Bu)3P / tetrahydrofuran / 0 - 20 °C

6.2: 69 percent / NaHCO₃; MCPBA / CH₂Cl₂ / 0 - 10 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

7.2: tetrahydrofuran; hexane / 0.75 h / -78 °C

8.1: tetrahydrofuran; hexane / -78 - 20 °C

9.1: 130 mg / sodium amalgam / methanol; tetrahydrofuran / -78 °C

10.1: 76 percent / I₂; NaHCO₃ / acetonitrile / 96 h / 40 °C

With sodium periodate; sodium amalgam; copper(l) iodide; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; N-methyl-2-indolinone; tributylphosphine; Amberlyst H-15; iodine; sodium hydrogencarbonate; In tetrahydrofuran; methanol; diethyl ether; hexane; water; acetonitrile; 1.1: Grignard reaction / 1.2: Grignard reaction / 7.2: Julia coupling;
DOI:10.1271/bbb.65.2630

Reference yield:

: 406673-97-0
(2S,3R)-1-benzyloxy-2-methyl-6-hepten-3-ol

: 406674-46-2
(2S,3R,6S,7R,8S)-1-benzyloxy-8-(tert-butyldimethylsilyl)oxy-3,6-epoxy-7-iodo-2-methylundecane

Guidance literature:: Multi-step reaction with 9 steps

1.1: 78 percent / Amberlyst H-15 / hexane / -78 - 20 °C

2.1: NMO; OsO₄ / tetrahydrofuran; H₂O / 0 - 20 °C

3.1: NaIO₄ / tetrahydrofuran; H₂O / 0.5 h / 20 °C

4.1: 0.43 g / LiAlH₄ / diethyl ether / 2 h / -78 °C

5.1: (n-Bu)3P / tetrahydrofuran / 0 - 20 °C

5.2: 69 percent / NaHCO₃; MCPBA / CH₂Cl₂ / 0 - 10 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

6.2: tetrahydrofuran; hexane / 0.75 h / -78 °C

7.1: tetrahydrofuran; hexane / -78 - 20 °C

8.1: 130 mg / sodium amalgam / methanol; tetrahydrofuran / -78 °C

9.1: 76 percent / I₂; NaHCO₃ / acetonitrile / 96 h / 40 °C

With sodium periodate; sodium amalgam; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; N-methyl-2-indolinone; tributylphosphine; Amberlyst H-15; iodine; sodium hydrogencarbonate; In tetrahydrofuran; methanol; diethyl ether; hexane; water; acetonitrile; 6.2: Julia coupling;
DOI:10.1271/bbb.65.2630