81380-10-1

Upstream product

• 57280-24-7 (R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol 
• 100-39-0 benzyl bromide 
• 59005-41-3 (2R,3S)-4-Benzyloxy-3-methyl-butane-1,2-diol 
• 81380-11-2 Toluene-4-sulfonic acid (1S,2R)-3-benzyloxy-1-hydroxymethyl-2-methyl-propyl ester 
• 80184-02-7 (2S,3S)-4-(benzyloxy)-3-methyl-1,2-butanediol 
• 97747-37-0 (1S,3S,4S)-3-hydroxymethyl-4-methyl-1-phenyl-1,3-dioxane 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 406673-97-0 (2S,3R)-1-benzyloxy-2-methyl-6-hepten-3-ol 
• 81380-07-6 (2R,3S,6S)-1-Benzyloxy-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-heptan-3-ol 
• 81380-07-6 (2S,3R,6S)-1-Benzyloxy-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-heptan-3-ol 
• 81380-07-6 (2S,3S,6S)-1-Benzyloxy-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-heptan-3-ol 
• 80109-44-0 (2S,3S,6S)-1-Benzyloxy-2-methyl-6-(R)-oxiranyl-heptan-3-ol 
• 81380-09-8 [(2R,3S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-methanol 

Relevant academic research and scientific papers

Spirastrellolide E: Synthesis of an advanced C(1)-C(24) southern hemisphere

The synthesis of a C(1)-C(24) advanced southern hemisphere fragment towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chemistry (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.

Total synthesis of the polyene macrolide antibiotic roxaticin. I. Synthesis of the polyol fragment of roxaticin using a four-carbon chain extension strategy

The C11-C26 polyol fragment of roxaticin containing eight chiral centers has been prepared in a reiterative manner using coupling reactions of chiral dithianes and epoxides followed by stereoselective reduction.

Studies toward polyether antibiotics: stereospecific synthesis of polysubstituted tetrhydropyrans

A stereospecific and general method for the preparartion of trans-tetrahydropyrans 1 and cis-tetrahydropyrans 2 from acyclic precursors are described.Compound 12, a possible intermediate for the synthesis of antibiotic X-14547A, has been synthesized.